WCN26-6340 Enrichment of Acidification Pathways in Tubules at Early Cystogenesis Stage of mTOR-Overactivated, Polycystic Kidney Disease Model

Le résumé fourni par la source

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary diseases and is primarily caused by mutations in the PKD1 or PKD2 gene, encoding polycystin 1 (PC1) and 2 (PC2). The PC1/2 forms a cell-surface complex in the primary cilia of renal tubular cells. mTOR is a master regulator of cell proliferation and nutrition that is localized in the lysosome membrane. The mTOR signal is primarily regulated by the TSC1 and 2 and is associated with PC1/2 function and localization. Dysregulation of mTOR is implicated in cystogenesis of the human ADPKD and Pkd1-KO mice.

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