Advances in sensor integration for real-time monitoring of joint-on-chips

Le résumé fourni par la source

Joint-on-chip (JoC) platforms represent a transformative approach to modeling the complex functional units of joints, offering valuable tools for disease modeling, drug discovery, and biomarker identification. However, the field faces two key challenges: the accurate recapitulation of the multifaceted joint environment and the lack of integrated online readouts to monitor cellular and tissue responses in real-time. This review underscores the importance of capturing the interplay of joint tissues and highlights the potential of diverse monitoring strategies—including optical, electrical, mechanical, and biochemical modalities—for real-time assessment. Drawing on examples from musculoskeletal and other organ-on-chip systems, we discuss current advancements and gaps in the field. Finally, we provide a forward-looking perspective on how addressing these limitations can accelerate the development of robust JoC platforms for translational musculoskeletal research.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.