Investigation of Serum Krebs von den Lungen-6 Level in Patients with Bone Sarcoma and Lung Metastasis
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Le résumé fourni par la source
OBJECTIVE: Serum Krebs von den Lungen-6 (KL-6) level increases in interstitial lung disease and lung cancer. The present study investigated whether there was an increase in serum KL-6 levels in patients with bone sarcoma who were considered positive for lung metastasis. MATERIALS AND METHODS: Serum samples were collected from patients diagnosed with Ewing sarcoma and osteosarcoma before starting chemotherapy. The samples were frozen and stored at -80°C, and serum KL-6 level was measured using enzyme-linked immunosorbent assay. RESULTS: Serum samples of 47 patients and 42 healthy volunteers were evaluated. At the time of diagnosis, 10 patients had pulmonary tumor metastasis. Patients were followed up for a median of 43 months (1-125 months). At the time of diagnosis, the median KL-6 level of patients with lung metastases was 38.15 U/mL (10.6-155.6 U/mL), while the KL-6 level of patients without lung metastases was 15.2 U/mL (10.7-188.3 U/mL). The difference between these 2 groups was borderline significant (P = .051). The median KL-6 value of the control group was 14.85 U/mL (10.3-188.6 U/mL). When the patients with lung metastasis at the time of diagnosis were compared with the healthy control group, the KL-6 level of the patients was statistically significantly higher than the control group (P = .017). CONCLUSION: In this pilot study, it was found that serum KL-6 levels were elevated in patients with lung metastasis at the time of diagnosis compared to healthy controls. Serum KL-6 level may be used as an additional parameter to detect pulmonary metastasis, and further studies are needed to confirm this observation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Investigation of Serum Krebs von den Lungen-6 Level in Patients with Bone Sarcoma and Lung Metastasis
- Date Crossref
- 23/03/2026
- Éditeur
- Caleo
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ankara University pays non établi dans la noticeUniversité ou école supérieure
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Memorial Ankara Hospital pays non établi dans la noticeÉtablissement de santé
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Başkent University Hospital pays non établi dans la noticeÉtablissement de santé
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University of Health Science Department of Pediatric Hematology and Oncology pays non établi dans la noticeUniversité ou école supérieure
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Sağlık Bilimleri Üniversitesi pays non établi dans la noticeUniversité ou école supérieure
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Ankara Onkoloji Eğitim ve Araştırma Hastanesi pays non établi dans la noticeÉtablissement de santé
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Ankara Yıldırım Beyazıt University Department of Pediatric Hematology and Oncology pays non établi dans la noticeUniversité ou école supérieure
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Pediatric Stem Cell Laboratory pays non établi dans la noticeStructure de recherche
Ankara University, Memorial Ankara Hospital et Başkent University Hospital, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.