Targeted Peri-operative Prophylaxis in Patients Colonized With Carbapenem Resistant Enterobacterales Undergoing Liver Transplantation: A Multinational Cohort Study
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Le résumé fourni par la source
BACKGROUND: Targeted perioperative prophylaxis (T-PAP) has been proposed to mitigate the impact of Carbapenem-Resistant Enterobacterales (CRE) infections in patients colonized with CRE who are undergoing liver transplantation (LT). This study aims to investigate the impact of T-PAP versus standard perioperative prophylaxis (S-PAP) in preventing CRE infections. METHODS: Observational, multinational cohort study of adults with CRE colonization at LT. The endpoints were CRE infection within 15 and 30 days after LT. Exposure was T-PAP defined as the use of agents with in vitro activity against the colonizing strain. T-PAP was differentiated into T-PAP with old drugs (T-PAPold) and T-PAP with novel drugs (T-PAPnew) according to the regimens used. T-PAPnew included patients exposed to new betalactam/betalactamse inhibitors (BL/BLIs) or cefiderocol. Treatment-effect models with augmented inverse probability weighting were employed to assess the average treatment effect (ATE) of T-PAPold and T-PAPnew versus S-PAP on CRE infection. RESULTS: A total of 408 CRE pre-transplant carriers were included. T-PAPold was administered to 112 patients (27.5%), and T-PAPnew was administered to 28 patients (6.9%). Post-transplant CRE infection at 15 and 30 days occurred in 87 (21.4%) and 106 (26.0%) patients, respectively. The ATE of T-PAPnew at 15 and 30 days post-transplant was -0.146 (p=0.002) and -0.056 (p=0.320), respectively. The ATE of TPAPold at 15 and 30 days post-transplant was 0.003 (p=0.941) and -0.005 (p=0.897) respectively. CONCLUSIONS: The protective effect of T-PAPnew in preventing CRE infections is significant within the first 15 days, but its effectiveness decreases within the first month.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Targeted Peri-operative Prophylaxis in Patients Colonized With Carbapenem Resistant Enterobacterales Undergoing Liver Transplantation: A Multinational Cohort Study
- Date Crossref
- 25/03/2026
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Azienda USL di Bologna pays non établi dans la noticeÉtablissement de santé
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University of Bologna Department of Medical and Surgical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo Working Committee for Hospital Epidemiology and Infection Control pays non établi dans la noticeÉtablissement de santé
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Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione pays non établi dans la noticeÉtablissement de santé
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Azienda Ospedaliera Citta' della Salute e della Scienza di Torino pays non établi dans la noticeÉtablissement de santé
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University of Padua pays non établi dans la noticeUniversité ou école supérieure
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D’Or Institute for Research and Education pays non établi dans la noticeOrganisation à but non lucratif
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Hospital Israelita Albert Einstein Infectious Diseases Unit pays non établi dans la noticeOrganisme public
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Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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Azienda USL di Bologna, Department of Medical and Surgical Sciences — University of Bologna et Working Committee for Hospital Epidemiology and Infection Control — Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.