1210: EFFECTIVENESS OF MAGNESIUM SULFATE FOR CRITICAL ASTHMA IN THE PEDIATRIC INTENSIVE CARE UNIT
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Le résumé fourni par la source
Introduction: Magnesium sulfate (MgSO4) is an adjunctive therapy used in children with critical asthma refractory to conventional treatment. The primary aim of this study is to evaluate the efficacy of MgSO4 administration in pediatric patients admitted to the pediatric intensive care unit (PICU) with critical asthma. We hypothesized that MgSO4 administration would decrease both time on continuous albuterol and hospital length of stay, regardless of severity of illness. Methods: We conducted a retrospective cohort analysis of pediatric patients admitted to two PICUs: St. Christopher’s Hospital (Center-1) and UW Health American Family Children’s Hospital (Center-2), between 2015 and 2022. Patients were categorized into two groups: MgSO₄-treated and untreated. Continuous variables were compared between groups using the Wilcoxon rank-sum test and categorical variables compared using chi-square or Fisher’s exact tests. Outcomes involving duration length of stay (LOS), duration of oxygen support, and duration of continuous albuterol, were further explored using multivariable regression after log-transformation of time. Results: A total of 369 patients were included in the study. Median [IQR] age was 7 [4–11] years. Patients at Center-2 were 38% more likely to receive MgSO4 compared to those at Center 1 (36.1% vs 26.2%; RR=1.38, 95% CI: 1.01–1.88, p=0.04) during their hospitalization. PRISM-3 scores were significantly higher in the MgSO4 group (p=0.008), with each additional point in PRISM-3 associated with an 8% higher likelihood of receiving MgSO4 (RR=1.08; 95% CI = 1.03–1.12). Children treated with MgSO₄ received longer courses of corticosteroids (p=0.014). Median PICU (2.5 vs. 1.5 days; 95% CI=1.5–1.9) and hospital LOS (3.8 vs. 2.4 days; 95% CI=1.4–1.8) were both significantly greater in the MgSO4 group (p< 0.001). After regression analysis adjustment for differences between groups, we found that the duration and overall dose of continuous albuterol were also significantly higher in MgSO4-treated patients (p< 0.001). Conclusions: This multicenter cohort study of critically ill children with critical asthma found MgSO₄ was more often administered to patients with greater illness severity. Its use was associated with longer durations of continuous albuterol and LOS.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- 1210: EFFECTIVENESS OF MAGNESIUM SULFATE FOR CRITICAL ASTHMA IN THE PEDIATRIC INTENSIVE CARE UNIT
- Date Crossref
- 01/03/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Wisconsin–Madison pays non établi dans la noticeUniversité ou école supérieure
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Drexel University pays non établi dans la noticeUniversité ou école supérieure
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UW Health University Hospital pays non établi dans la noticeÉtablissement de santé
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St. Christopher's Hospital for Children pays non établi dans la noticeÉtablissement de santé
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University of Wisconsin School of Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Wisconsin-Madison Department of Biostatistics and Medical Informatics pays non établi dans la noticeUniversité ou école supérieure
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Oklahoma University pays non établi dans la noticeUniversité ou école supérieure
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University of Wisconsin Hospital and Clinics pays non établi dans la noticeUniversité ou école supérieure
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Saint Christopher’s Hospital for Children pays non établi dans la noticeÉtablissement de santé
University of Wisconsin–Madison, Drexel University et UW Health University Hospital, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.