Accès ouvert déclaré
2026
article
Per- and Polyfluoroalkyl Substances During Pregnancy and Gestational Diabetes: The Environmental Influences on Child Health Outcomes (ECHO) Cohort
Anne P. Starling, Mohamad Burjak, Adaeze W. Nzegwu, Xiaoshuang Xun, John L. Adgate, Emily S. Barrett, Deborah H. Bennett, Leda Chatzi, Elena Colicino, Dana Dabelea, Anne L. Dunlop, Stephanie M. Eick, Shohreh F. Farzan, Assiamira Ferrara, Abby F. Fleisch, Sarah D. Geiger, Monique M. Hedderson, Linda G. Kahn, Margaret R. Karagas, Rachel S. Kelly, Donghai Liang, Pi-i Lin, Thomas G. O’Connor, Amy M. Padula, Alicia K. Peterson, Megan E. Romano, Sheela Sathyanarayana, Yeyi Zhu, Damaskini Valvi, P. Brian Smith, L. Kristin Newby, Linda Adair, Lisa P. Jacobson, Diane Catellier, Monica McGrath, Christian Douglas, Priya Duggal, Emily Knapp, Amii Kress, Courtney K. Blackwell, Maxwell A. Mansoff, Jin-Shei Lai, Emily Ho, David Cella, Richard Gershon, Michelle Macy, Suman R. Das, Jane E. Freedman, Simon A. Mallal, John A. McLean, Ravi V. Shah, Meghan H. Shilts, Akram N. Alshawabkeh, Jose F. Cordero, John Meeker, Leonardo Trasande, Carlos A. Camargo, Kohei Hasegawa, Zhaozhong Zhu, Ashley F. Sullivan, Wei Perng, Traci A. Bekelman, Greta Wilkening, Sheryl Magzamen, Brianna F. Moore, Anne P. Starling, Deborah J. Rinehart, Daphne Koinis Mitchell, Viren D’Sa, Sean Deoni, Hans-Georg Mueller, Cristiane S. Duarte, Catherine Monk, Glorisa Canino, Jonathan Posner, Tenneill Murray, Claudia Lugo-Candelas, Patricia A. Brennan, Christine Hockett, Amy Elliott, Lisa A. Croen, John Ainsworth, Leonard B. Bacharier, Casper G. Bendixsen, James E. Gern, Diane R. Gold, Tina V. Hartert, Daniel J. Jackson, Christine C. Johnson, Christine L.M. Joseph, Meyer Kattan, Gurjit K. Khurana Hershey, Lemanske, Susan V. Lynch, Rachel L. Miller, George O'connor, Carole Ober, Dennis Ownby, Katherine Rivera‐Spoljaric, Patrick H. Ryan, Christine M. Seroogy, Anne Marie Singh, Robert A. Wood, Edward M. Zoratti, Rima Habre, Shohreh Farzan, Frank D. Gilliland, Irva Hertz-Picciotto, Julie B. Schweitzer, Rebecca J. Schmidt, Janine M. LaSalle, Alison E. Hipwell, Catherine J. Karr, Nicole R. Bush, Kaja Z. LeWinn, Qi Zhao, Frances Tylavsky, Kecia N. Carroll, Christine T. Loftus, Leslie D. Leve, Jody M. Ganiban, Jenae M. Neiderhiser, Scott T. Weiss, Augusto A. Litonjua, Cindy T. McEvoy, Eliot R. Spindel, Robert S. Tepper, Craig J. Newschaffer, Kristen Lyall, Heather E. Volk, Rebecca Landa, Sally Ozonoff, Joseph Piven, Heather Hazlett, Juhi Pandey, Robert Schultz, Steven Dager, Kelly Botteron, Daniel Messinger, Wendy Stone, J. C. Ames, Richard K. Miller, Emily Oken, Michele R. Hacker, Tamarra James-Todd, T. Michael O’Shea, Rebecca C. Fry, Jean A. Frazier, Rachana Singh, Caitlin Rollins, Angela Montgomery, Ruben Vaidya, Robert M. Joseph, Lisa K. Washburn, Semsa Gogcu, K. Bear, Julie V. Rollins, Stephen R. Hooper, Geneviève Taylor, Wesley Jackson, Amanda Thompson, Julie Daniels, Michelle Hernandez, Kun Lu, Michael Msall, Madeleine Lenski, Rawad Obeid, Steven L. Pastyrnak, Elizabeth Jensen, Christina Sakai, Hudson Santos, Jean M. Kerver, Nigel Paneth, Charles J. Barone, Michael R. Elliott, Douglas M. Ruden, Chris Fussman, Julie B. Herbstman, Amy Margolis, Susan L. Schantz, Sarah Dee Geiger, Andrea Aguiar, Karen Tabb, Rita Strakovsky, Tracey Woodruff, Rachel Morello-Frosch, Amy Padula, Joseph B. Stanford, Christina A. Porucznik, Angelo P. Giardino, Rosalind J. Wright, Robert O. Wright, Brent Collett, Nicole Baumann-Blackmore, Ronald Gangnon, Chris McKennan, Jo Wilson, Matt Altman, Judy L. Aschner, Annemarie Stroustrup, Stephanie L. Merhar, Paul E. Moore, Gloria Pryhuber, Mark Hudak, Ann Marie Reynolds Lyndaker, Andrea Lampland, Burton Rochelson, Sophia Jan, Matthew J. Blitz, Michelle W. Katzow, Zenobia Brown, Codruta Chiuzan, Timothy Rafael, Dawnette Lewis, Natalie Meirowitz, Brenda Poindexter, Tebeb Gebretsadik, Sarah Osmundson, Jennifer K. Straughen, Amy Eapen, Andrea Cassidy-Bushrow, Ganesa Wegienka, Alex Sitarik, Kim Woodcroft, Audrey Urquhart, Albert Levin, Tisa Johnson-Hooper, Brent Davidson, Tengfei Ma, Martin J. Blaser, Maria Gloria Dominguez-Bello, Daniel B. Horton, Manuel Jimenez, Todd Rosen, Kristy Palomares, Lyndsay A. Avalos, Kelly J. Hunt, Roger B. Newman, Michael S. Bloom, Mallory H. Alkis, James R. Roberts, Sunni L. Mumford, Heather H. Burris, Sara B. DeMauro, Lynn M. Yee, A Hamvas, Antonia F. Olidipo, Andrew Haddad, Lisa R. Eiland, Nicole T. Spillane, Kirin Suri, Stephanie A. Fisher, Jeffrey A. Goldstein, Leena B. Mithal, Raye-Ann O. DeRegnier, Nathalie L. Maitre, Ruby H.N. Nguyen, Meghan M. JaKa, Abbey C. Sidebottom, Michael J. Paidas, JoNell Potter, Natale Ruby, Lunthita Duthely, Arumugam Jayakumar, Karen Young, Isabel Maldonado, Meghan Miller, Jonathan L. Slaughter, Sarah A. Keim, Courtney D. Lynch, Kartik K. Venkatesh, Kristina W. Whitworth, Elaine Symanski, Thomas F. Northrup, Hector Mendez-Figueroa, Ricardo A. Mosquera, Juliette C. Madan, Debra M. MacKenzie, Johnnye L. Lewis, Brandon J. Rennie, Bennett Leventhal, Young Shin Kim, Somer Bishop, Sara S. Nozadi, Li Luo, Barry M. Lester, Carmen J. Marsit, Todd Everson, Cynthia M. Loncar, Elisabeth C. McGowan, Stephen J. Sheinkopf, Brian S. Carter, Jennifer Check, Jennifer Helderman, Charles R. Neal, Lynne M. Smith.
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Résumé fourni par la source
OBJECTIVE: Exposure to per- and polyfluoroalkyl substances (PFAS) may increase the risk of gestational diabetes mellitus (GDM), with adverse consequences for pregnant women and their offspring. However, epidemiologic studies have shown inconsistent results. We addressed this question in a large, pooled sample of U.S. women. RESEARCH DESIGN AND METHODS: Participants (n = 5,229) from 16 cohorts had singleton pregnancies. PFAS were quantified in a single plasma or serum sample during pregnancy (1999-2021); six PFAS detected in ≥60% of participants were analyzed. The primary outcome was GDM diagnosis based on self-report or medical record documentation. The secondary outcome, among 1,213 participants, was fasting glucose. We estimated associations between each PFAS and GDM using generalized estimating equations models with Poisson distribution and robust variance, and estimated associations between each PFAS and fasting glucose using generalized estimating equations models for linear regression. Effect modification by prepregnancy BMI or race and ethnicity was evaluated via interaction terms and stratification. We quantified the combined effect of the PFAS mixture using quantile-based g-computation. RESULTS: Associations between individual PFAS and GDM were null or weakly inverse; the association with the six-PFAS mixture was negative (prevalence ratio [95% CI] per quartile increase: 0.75 [0.58, 0.96]). Certain PFAS were more strongly negatively associated with GDM among participants with BMI <25 kg/m2. Associations between PFAS and fasting glucose were largely null, although both positive and negative associations were observed in specific race and ethnicity strata. CONCLUSIONS: In a large, pooled sample of U.S. pregnant women, greater concentrations of PFAS were not associated with higher prevalence of GDM.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Per- and Polyfluoroalkyl Substances During Pregnancy and Gestational Diabetes: The Environmental Influences on Child Health Outcomes (ECHO) Cohort
- Date Crossref
- 24/03/2026
- Éditeur
- American Diabetes Association
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
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Sujets associés
Per- and polyfluoroalkyl substances researchToxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicals