Systemic inflammation parameters in chronic myocarditis in patients with atrial fibrillation

Résumé fourni par la source

Aim. To evaluate parameters of the systemic inflammatory response in myocarditis in patients with atrial fibrillation. Material and methods. The study sample included 63 patients undergoing inpatient interventional treatment for atrial fibrillation. Of these, 49 (77,8%) were men. The median age was 46 (39; 54) years. During the catheter procedure, all patients underwent endomyocardial biopsy, followed by histological diagnosis. The role of systemic inflammation parameters in patients with and without myocarditis was retrospectively assessed. Results. Chronic myocarditis was detected in 30 patients (46,1%). The systemic inflammatory response index (SIRI) (p=0,04), total systemic inflammation index (SII) (p=0,02), and monocyte-to-lymphocyte ratio (MLR) (p=0,02) were significantly higher in the group without myocarditis. ROC curves for these parameters were analyzed. Multiple regression analysis revealed no predictive effect of these factors on myocarditis. Conclusion. The SIRI, SII, and MLR values were significantly higher in patients without myocarditis. The MLR was higher in patients with stage 2 and higher myocardial fibrosis. The SIRI and MLR were significantly lower in patients with higher EHRA score.

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