Hypoxia-related and immune phenotype-related fusion model for non-invasive prognostication of hepatocellular carcinoma treated by TACE: a multicentre study
Rattachement africain : hk, cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Survival outcomes after transarterial chemoembolisation (TACE) vary in hepatocellular carcinoma (HCC) patients, and existing prognostic scores and imaging models often lack generalisability and biological interpretability. OBJECTIVE: To develop and validate a multimodal prognostication model for HCC that allows for a precise assessment of survival outcomes of HCC patients receiving TACE therapy. DESIGN: This study enrolled 1448 HCC patients, including a TACE cohort (n=1349), a biomarker subset from a randomised trial (n=41), a single-cell RNA sequencing cohort and The Cancer Genome Atlas (TCGA) HCC cohort (n=50). Pre-treatment contrast-enhanced CT images were used to construct deep learning and conventional radiomic models. The early-fusion and late-fusion models (LFMs) were compared, and a clinical-radiologic model (CRM) was formed by integrating the better-performing LFM with clinical variables. Using TCGA data and single-cell transcriptomic profiles, the differences between high-score and low-score groups in tumour immune microenvironment, cellular functional states and key signalling pathways were investigated. RESULTS: The CRM effectively stratified patients' survival across multiple independent cohorts and achieved more granular risk stratification than the existing clinical models. Multi-omic analyses revealed that in the LFM high-score group, myelocytomatosis oncogene was activated, epithelial-mesenchymal transition enhanced, glycolysis upregulated and hypoxia pathway activated. Single-cell transcriptomic data confirmed that virtually all cell types in high-risk patients scored high in hypoxia, and cytotoxic T cells had a reduced cytotoxic activity. CONCLUSION: The CRM model can non-invasively predict the prognosis of HCC patients treated by TACE therapy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Hypoxia-related and immune phenotype-related fusion model for non-invasive prognostication of hepatocellular carcinoma treated by TACE: a multicentre study
- Date Crossref
- 19/03/2026
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Union Hospital pays non établi dans la noticeÉtablissement de santé
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Hubei Provincial Center for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing pays non établi dans la noticeStructure de recherche
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Huazhong University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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Hubei Cancer Hospital pays non établi dans la noticeÉtablissement de santé
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Yichang Central People's Hospital pays non établi dans la noticeÉtablissement de santé
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Guangxi Medical University Department of Interventional Radiology pays non établi dans la noticeUniversité ou école supérieure
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Kunming Medical University Department of Minimally Invasive Intervention pays non établi dans la noticeUniversité ou école supérieure
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The People's Hospital of Guangxi Zhuang Autonomous Region pays non établi dans la noticeÉtablissement de santé
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Sichuan Cancer Hospital pays non établi dans la noticeÉtablissement de santé
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Harbin Medical University Department of Radiology pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital of Harbin Medical University pays non établi dans la noticeÉtablissement de santé
Union Hospital, Hubei Provincial Center for Disease Control and Prevention et State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.