Autism outcomes and neurobehavioural markers in young children born to mothers with HIV in Kenya: a protocol for the Alama project
Rattachement africain : Kenya, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
INTRODUCTION: The over 14 million African children who are HIV-exposed but uninfected (CHEU) are at risk for poor health outcomes, including neurodevelopmental conditions such as autism; however, no study to date has examined autism in CHEU in Africa, where the vast majority of these children live. Scalable diagnostic and neurobehavioural tools, including powerful, low-cost approaches such as eye-tracking, for detection and study of mechanistic neural processes are necessary to advance autism research in these settings. The objective of this study is to examine autism diagnostic outcomes and eye-tracking biomarkers in relation to CHEU while at the same time building capacity for neuro-health research in Kenya. METHODS AND ANALYSIS: This study will leverage a longitudinally assessed cohort of CHEU and children who are HIV-unexposed and uninfected (CHUU) with well characterised HIV-related and contextual exposures. We will first determine and compare autism diagnostic outcomes between young CHEU and CHUU across a large cohort (n=850) of Kenyan children using research-grade autism assessment tools, and, second, determine whether neurobehavioural eye-tracking markers predict autism outcomes across this cohort. ETHICS AND DISSEMINATION: Human subjects approvals have been obtained from Moi University Institutional Review and Ethics Committee (IREC; IREC/909/2024; Approval #0004835), Kenya's National Commission for Science, Technology and Innovation (NACOSTI; Reference #NACOSTI/P/25/415028), the Institutional Review Board of the Indiana University School of Medicine (Protocol #23171), with reliance agreements executed with Purdue University and Boston University. Dissemination of findings will occur through multiple channels within the research and clinical community, including peer-reviewed journal publications and conference abstracts and presentations. As part of capacity building efforts, the research team will also communicate study results to policy makers, the lay public and other health systems involved in the care of young children with disabilities via study-hosted workshops and conferences.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Autism outcomes and neurobehavioural markers in young children born to mothers with HIV in Kenya: a protocol for the Alama project
- Date Crossref
- 01/03/2026
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Moi University Kenya (code pays fourni par la source)Université ou école supérieure
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AMPATH Kenya (code pays fourni par la source)Établissement de santé
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Purdue University West Lafayette Department of Psychological Sciences pays non établi dans la noticeUniversité ou école supérieure
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Indiana University School of Medicine Department of Pediatrics Eldoret, Kenya (pays nommé en fin d’affiliation)Université ou école supérieure
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Indiana University – Purdue University Indianapolis pays non établi dans la noticeUniversité ou école supérieure
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Boston University Department of Anatomy and Neurobiology pays non établi dans la noticeUniversité ou école supérieure
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Academic Model Providing Access to Healthcare Eldoret, Kenya (pays nommé en fin d’affiliation)Institution
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Moi Teaching and Referral Hospital Eldoret, Kenya (pays nommé en fin d’affiliation)Établissement de santé
Moi University (Kenya), AMPATH (Kenya) et Department of Psychological Sciences — Purdue University West Lafayette, avec 5 autres affiliations. Pays d’affiliation : Kenya.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.