Bioadhesive and hemostatic microneedles integrated with NIR-responsive Ti 3 C 2 /CeO 2 heterojunction nanozymes for accelerated diabetic wound healing
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Le résumé fourni par la source
Rationale: The hyperglycemic microenvironment and microvascular dysfunction in diabetic wounds induce excessive reactive oxygen species (ROS) accumulation and persistent bleeding, severely impeding healing.Conventional nanozymes can scavenge ROS by mimicking the activities of superoxide dismutase (SOD) and catalase (CAT), but generally exhibit low catalytic efficiency and poor physiological stability.Fabricating nanozyme heterojunctions offers a viable approach to circumventing the aforementioned drawbacks.Methods: TC (Ti3C2/CeO2) heterojunctions were fabricated via an etching step followed by a solvothermal approach.The TC nanosheets were incorporated into a GelMA hydrogel to form the tip layer, while methacrylated dopamine (DMA) was integrated into the base layer for bio-adhesive functionality.A bilayer microneedle patch (GTM) was fabricated via a two-step photopolymerization process.The hemostatic capacity, photothermal conversion, and antioxidation properties were systematically examined in vitro.Meanwhile, animal experiments were executed utilizing a rabbit model of hepatic bleeding and a severe cutaneous defect model in diabetic Sprague-Dawley (SD) rats.Results: Under NIR irradiation, the TC heterojunction exhibited significantly enhanced antioxidant enzymatic activity, driven by synergistic interfacial charge transfer and photothermal effects.The bio-adhesive base layer achieved rapid hemostasis in a hepatic hemorrhage model, reducing blood loss from 6.51 g to 0.93 g.A highly accelerated wound healing process was observed in a diabetic rat model of full-thickness skin defects following treatment with GTM under NIR irradiation, achieving 99.89% wound closure by Day 20 while alleviating oxidative stress and promoting collagen deposition.Conclusion: This study developed a bifunctional wound repair platform by integrating a strongly adhesive microneedle base with NIR-responsive heterojunction nanozymes, providing novel insights for overcoming challenges in diabetic wound healing.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Bioadhesive and hemostatic microneedles integrated with NIR-responsive Ti <sub>3</sub> C <sub>2</sub> /CeO <sub>2</sub> heterojunction nanozymes for accelerated diabetic wound healing
- Date Crossref
- 09/03/2026
- Éditeur
- Ivyspring International Publisher
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Wuhan University Department of Urology pays non établi dans la noticeUniversité ou école supérieure
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Zhongnan Hospital of Wuhan University pays non établi dans la noticeÉtablissement de santé
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Hubei University pays non établi dans la noticeUniversité ou école supérieure
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Union Hospital pays non établi dans la noticeÉtablissement de santé
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College of Health Science and Engineering Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine pays non établi dans la noticeUniversité ou école supérieure
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School of Life Sciences Stem Cells and Tissue Engineering Manufacture Center pays non établi dans la noticeUniversité ou école supérieure
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TaiKang Medical School (School of Basic Medical Sciences) Department of Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
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Tongji Medical College Department of Nuclear Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Urology — Wuhan University, Zhongnan Hospital of Wuhan University et Hubei University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.