obophenotype/cell-ontology: 2026-03-17 Release

Le résumé fourni par la source

Release Notes 2026-03-17 Ontology content summary | Metric | Value | |:------------------------------------------------|--------:| | Number of subclasses of root | 3306 | | Number of annotations on CL terms | 17273 | | Number of synonyms | 7099 | | Number of unique references | 1960 | | Number of unique references in definitions | 2065 | | Number of relationships with CL term as subject | 5092 | | Number of cellxgene classes | 1026 | | Number of HRA classes | 612 | Classes added: 78 | Term | ----| | lumbar dorsal root ganglion TRPV1 neuron (CL:4079019) | | sacral dorsal root ganglion Piezo2 neuron (CL:4079025) | | intrinsic cardiac ganglion TH neuron (CL:4079010) | | dorsal root ganglion Nav1.7 neuron (CL:4033178) | | cervical dorsal root ganglion endothelin-1 neuron (CL:4079001) | | intestinofugal neuron (CL:0020049) | | oRGC2 (CL:0020032) | | middle zone articular chondrocyte (CL:0020038) | | cervical dorsal root ganglion Nav1.9 neuron (CL:4079003) | | secretomotor/vasodilator neuron of myenteric plexus (CL:0020048) | | dorsal root ganglion EDN1 neuron (CL:4033177) | | thoracic dorsal root ganglion CGRP neuron (CL:4079029) | | lumbar dorsal root ganglion RET neuron (CL:4079017) | | dorsal root ganglion Nav1.9 neuron (CL:4033179) | | cervical dorsal root ganglion Piezo2 neuron (CL:4079005) | | oRGC1 (CL:0020036) | | cervical dorsal root ganglion TRPV1 neuron (CL:4079008) | | calcified zone articular chondrocyte (CL:0020040) | | oRGC5 (CL:0020042) | | sacral dorsal root ganglion RET neuron (CL:4079026) | | stubby Dogiel type I neuron of myenteric plexus (CL:0020052) | | lumbar dorsal root ganglion peripherin neuron (CL:4079015) | | cuboidal epithelial cell (CL:0020029) | | lumbar dorsal root ganglion CGRP neuron (CL:4079011) | | thoracic dorsal root ganglion RET neuron (CL:4079035) | | cervical dorsal root ganglion RET neuron (CL:4079006) | | sacral dorsal root ganglion substance P neuron (CL:4079027) | | intestinal intraepithelial lymphocyte (CL:0020035) | | thoracic dorsal root ganglion peripherin neuron (CL:4079033) | | calretinin-positive intrinsic primary afferent neuron of myenteric plexus (CL:0020055) | | cervical dorsal root ganglion Nav1.7 neuron (CL:4079002) | | spiny Dogiel type I neuron of myenteric plexus (CL:0020053) | | dorsal root ganglion RET neuron (CL:4033182) | | ascending interneuron of myenteric plexus (CL:0020050) | | stem cell memory CD8-positive, alpha-beta T cell (CL:0020034) | | thoracic dorsal root ganglion TRPV1 neuron (CL:4079037) | | Dogiel type II neuron (CL:0020045) | | dorsal root ganglion peripherin neuron (CL:4033180) | | Dogiel type II neuron of myenteric plexus (CL:0020054) | | intrinsic primary afferent neuron of myenteric plexus (CL:0020046) | | lumbar dorsal root ganglion Piezo2 neuron (CL:4079016) | | CD4-positive exhausted alpha-beta T cell (CL:0020030) | | sacral dorsal root ganglion Nav1.9 neuron (CL:4079023) | | thoracic dorsal root ganglion endothelin-1 neuron (CL:4079030) | | migratory muscle precursor (CL:0020044) | | interneuron of myenteric plexus (CL:0020047) | | thoracic dorsal root ganglion Piezo2 neuron (CL:4079034) | | hybrid osteochondral skeletal cell (CL:0020028) | | thoracic dorsal root ganglion Nav1.9 neuron (CL:4079032) | | lumbar dorsal root ganglion Nav1.9 neuron (CL:4079014) | | calretinin-negative intrinsic primary afferent neuron of myenteric plexus (CL:0020056) | | sacral dorsal root ganglion CGRP neuron (CL:4079020) | | dorsal root ganglion SP neuron (CL:4033183) | | fasciacyte (CL:0020043) | | stem cell memory CD4-positive, alpha-beta T cell (CL:0020033) | | dorsal root ganglion Piezo2 neuron (CL:4033181) | | dorsal root ganglion BRN3A neuron (CL:4033175) | | cervical dorsal root ganglion CGRP neuron (CL:4079000) | | thoracic dorsal root ganglion substance P neuron (CL:4079036) | | sacral dorsal root ganglion endothelin-1 neuron (CL:4079021) | | cervical dorsal root ganglion peripherin neuron (CL:4079004) | | thoracic dorsal root ganglion Nav1.7 neuron (CL:4079031) | | nitrergic neuron of myenteric plexus (CL:0020058) | | cervical dorsal root ganglion substance P neuron (CL:4079007) | | lumbar dorsal root ganglion Nav1.7 neuron (CL:4079013) | | sacral dorsal root ganglion TRPV1 neuron (CL:4079028) | | sacral dorsal root ganglion peripherin neuron (CL:4079024) | | sacral dorsal root ganglion Nav1.7 neuron (CL:4079022) | | CD8-positive exhausted alpha-beta T cell (CL:0020031) | | superficial zone articular chondrocyte (CL:0020037) | | lumbar dorsal root ganglion endothelin-1 neuron (CL:4079012) | | dorsal root ganglion TRPV1 neuron (CL:4033184) | | cholinergic neuron of myenteric plexus (CL:0020057) | | descending interneuron of myenteric plexus (CL:0020051) | | deep zone articular chondrocyte (CL:0020039) | | lumbar dorsal root ganglion substance P neuron (CL:4079018) | | oRGC4 (CL:0020041) | | dorsal root ganglion CGRP neuron (CL:4033176) | Text definitions added: 79 | Term | New Text Definition | ----|----| | migratory muscle precursor (CL:0020044) | Muscle precursor cells that delaminate from the dermomyotome after epithelial-to-mesenchymal transition (EMT) and undergo long-range migration while retaining proliferative capacity. | | dorsal root ganglion RET neuron (CL:4033182) | A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker proto-oncogene tyrosine-protein kinase receptor Ret (RET). RET is present in approximately 46% of TrkA-positive human DRG neurons and marks the non-peptidergic nociceptor population. | | thoracic dorsal root ganglion RET neuron (CL:4079035) | A non-peptidergic nociceptor whose soma is located in the thoracic dorsal root ganglion and that expresses the receptor tyrosine kinase RET (encoded by RET). This neuron is distinguished from peptidergic nociceptors by its dependence on glial cell-derived neurotrophic factor family ligands rather than nerve growth factor, and in rodents it characteristically binds isolectin B4. In human DRG, RET-immunoreactive neurons constitute approximately 46% of TrkA-positive neurons, a significantly higher proportion than the 23% observed in mouse (Rostock et al. 2018, PMID:29229553), indicating an expanded non-peptidergic nociceptor compartment in humans. | | Dogiel type II neuron (CL:0020045) | A neuron characterised by Dogiel type II morphology: a large, smooth, oval soma bearing multiple long axon-like processes (multiaxonal) that extend without branching until they reach their targets. The soma lacks the short lamellar or spiny dendrites characteristic of Dogiel type I neurons. Dogiel type II neurons were first described by Alexander Dogiel in 1899 based on methylene blue staining in gastrointestinal ganglia. In the enteric nervous system, Dogiel type II neurons correspond to intrinsic primary afferent neurons (IPANs) and exhibit AH-type electrophysiology (prolonged afterhyperpolarization following an action potential). | | dorsal root ganglion Nav1.7 neuron (CL:4033178) | A sensory neuron that has the soma located in the dorsal root ganglion and expresses the marker sodium channel protein type 9 subunit alpha (Nav1.7/SCN9A). Nav1.7 accounts for approximately 50% of total sodium channel expression in human DRG and is present in 54-57% of TrkA-positive nociceptors. | | thoracic dorsal root ganglion endothelin-1 neuron (CL:4079030) | A sensory neuron whose soma is located in the thoracic dorsal root ganglion and that expresses endothelin-1 (EDN1). In rat DRG, EDN1 immunoreactivity has been detected in a subset of neuron somata (Giaid et al. 1989, PMID:2678100). Endothelin-1 acts as an endogenous pain mediator, sensitizing nociceptors through activation of ETA and ETB receptors, and these neurons are implicated in vascular pain signalling. EDN1-expressing DRG neurons have been characterized in rat; their prevalence and properties in human DRG remain to be systematically determined, as EDN1 is not yet represented in human DRG single-cell transcriptomic datasets. | | lumbar dorsal r

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.