Accès ouvert déclaré
2026
article
ICU-acquired infection in neutropenic patients
Océane Bernard de Lajartre, Nicolas Massart, Florian Reizine, Anaïs Machut, Charles‐Hervé Vacheron, Anne Savey, Arnaud Friggeri, Alain Lepape, the REA-REZO study group, Abdelkrim Abdelmalek, Francoise Adema, S. Alfandari, Alexandra Allaire, Antonio Álvarez, Nacim Ammenouche, Laurent Argaus, Gérard Audibert, Caroline Aurel, Odile Bajolet, Frédéric Barbut, Geneviève Barjon, Magali Bauer Grandpierre, P. Baune, Sébastien Beague, Bassam Beilouny, Nicolas Bèle, Nicolas Belin, Cécile Bernerd, Yasmina Berrouane, Aziz Berrouba, Julie Bertrand, Claire Bianchi, Sandrine Biangoma, Fabienne Birot Jaulin, Severine Bonjean, Michel Bonnivard, Stéphanie Bordes-Couecou, Abdenour Bouhara, Philippe Bouillard, Amine Bouriga, C. Bourigault, Sylvie Bourzeix, Nicolat Boussekey, Mathieu Boutonnet, S. Boutreux, Hanene Bouzidi, Julie Brochart, Stéphanie Bulyez, Laurianne Buyer, Marie Callanquin, Nathalie Canu, Morgan Caplan, Matthieu Capron, Daniel Carbognani, Vincent Castelain, Vincent Catanese, Isabelle Cattaneo, Vanessa Chartier, Guillaume Chassaing, Robert Chausset, Mélanie Chauvet, Fabrice Chopin, Catherine Chubilleau, Céline Clayer, Sylvie Comparot, P. Corne, Marie-Elisabeth Cornesse, Gaëlle Corno, Esther Cortes, Gaëlle Cosmao, Patricia Courouble, Christian Crombé, Véronique Curnier, Caroline Cyvoct, Monzer Dabbachi, Cédric Dananché, Abla Daroukh, Damien Dassant, Martine Daumas, Aurélien Daurat, Dominique Deffarges, F. Delanghe, Olivier Delastre, Joël Delhomme, Jean Paul Délias, Martine Delorme, Fabienne Derramond, Géraldine Dessertaine, Frédérique Diaw, Isabelle Dijols, Kamel Djedaini, Loïc Dopeux, Margaux Duboin, Jean-Louis Dubost, Sophie Duhoo, Thierry Dulac, Julien Dupeyrat, Clarisse Dupin, Laurène Nathalie Dupont, Matthieu Duprey, M. Durand, Isabelle Durand Joly, Jean-Yves Dusseau, Pierre Yves Egreteau, Carole Eldin, F. Espinasse, Éric Farfour, Abdelhamid Fatah, Yannick Fédun, Luis Vicente Ferreira, Pierre Fillatre, Toufic Finge, Véronique Fleurial, Arnaud Florentin, Candice Fontaine, A Fribourg, Severine Gallais-Hoff, Claude Galland, Richard Galliot, Sylvain Garnier, Gaëlle Gasan, Julien Gaubert-Duclos, Valérie Gauzere, T. Geffriaud, Isabelle Geneau, Hughes Georges, Solweig Gerbier Colomban, Christophe Giacardi, Sébastien Gibot, Audrey Glanard, Marion Gleize, Marieline Goret, F. Gourdon, Michele Gourgues, Delphine Grau, Béatrice Grisi, Clotilde Groleau, Liliane Grolier-bois, Catherine Guignabert, Sabrina Habchi, Fethi Hadj-slimane, Emmanuelle Hammad, Catherine Haond, Marie Hélène Hausermann, Françoise Hayo, Karim Hellal, C Henry, Alexandre Herbland, Julien Huntzinger, Hervé Hyvernat, Alexandre Jean, Asma Jeblaoui, B. Jolibois, Sylvie Joron, Gauthier Julien, Dominique Jusserand, Michel Kaidomar, Jean Kempf, Lyes Knani, Béatrice La Combe, Marie Labruyère, S. Lacroix, Bruno Lafon, Katia Lamant, Peggy Larroude, Anne Launoy, Bernadette Laurent, Thierry Lavigne, Christine Lawrence, Quoc Vien Le, Muriel Le Coq, Anne-Sophie Le Floch, Fanny Le Gall, Guillaume Loup, Brigitte Le Tallec, Lucie Lecoutre, Stanislas Ledochowski, Philippe Lehoux, Florence Lemann, Rusel Leon, Claire Lepouse, Thomas Lescot, Mélanie Levrard, Marie Laure Lier, Anne Lignereux, Aurore Loquet, Benjamin Louart, Claire Maheu, Aurélie Maindron, François Mallard, Marie Reine Mallaret, B. Mankikian, Christiane Manzon, Philippe Mardrus, J. Mariot, Audrey Martin, Emmanuelle Martin, Maelle Martin, Olivier Martinet, Pascale Martres, Virginie Maxime, Karim Merouani, Olivier Meunier, Ella-Pauline Meyer, Ferhat Meziani, Salman ben Abdel Aziz ben Salman ben Mohammad, Laure Mons, Sébastien Moschietto, Céline Muller, E. Munier-Marion, Jean-Christophe Navellou, C. Neulier, François Nicolas, Dominique Nicollon, Jacques-Yves Nizou, Abdelali Ouchikhe, Olivier Pajot, Christine Palitta, Michel Pascal, O. Passouant, René-Gilles Patrigeon, Frédérique Pavillard, Sabine PEGHAIRE, C. Perdrix, Johana Perez, Romain Persichini, Jean-Sebastien Petit, Judith Pibre, Walter Picard, Sylvie Picault, Santiago Gil, Jérôme Pillot, Patrick Inácio Pina, Blandine Placet, Gaëtan Plantefeve, Rémi Plattier, L. Poiron, Christian Pommier, Gaël Pradel, Cristian Prelipcean, Paul-Simon Pugliesi, Vincent Quenee, Julie Racaud, Céline Ragot, T.A.V. Randriamandrato, Olga Raposo, Eve Remy, Laeticia Renard, Sabine Reynaud Deforges, Gaelle Ribeyre, Jean-Christophe Richard, Sylvie Ricôme, Thomas Rimmele, Adrien Robine, Isabel Roca-Cerezo, Anne-Claude Roche, Laetitia Rohr, G. Rolland-Jacob, Antoine Romen, Adrien Roques, Catherine Rougier, Stéphane Rouleau, Jérôme Roustan, Laysa Saadi, Mélanie Saint-Leger, Faouzi Saliba, Dominique Sechaud, Nicholas Sedillot, Amine Si-ali, C. Simac, Georges Simon, Michel Sirodot, Aude Spitz, Vincent Stoeckel, Magdalena Szczot, Philippe Tagawa, Marine Tasle, Bertrand Texier, Fabrice Thiollière, Benoit Thiphagne, Aurélie Thomas-hervieu, François Tinturier, Alexandre Tonnelier, Alexandre Toro, David Tranvan, D Trivier, Gilles Troché, Rémi Trusson, Lionel Ursulet, M.L. Valdeyron, Catherine Vallet, Vanessa Van Rosse, Laurence Vasse, Myriam Venelle, C. Venot, Franck Verdonk, Antoine Vieillard-Baron, Jean-François Vincent, M Vitris, Emmanuel Vivier, Florent Wallet, Hussein N. Yassine, Lassane Zanre, Cécile Zylberfajn
0Citations signalées, ce qui n’est pas une note de qualité
9Institutions déclarées
2Pays d’affiliation déclarés
Rattachement africain : fr, us.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Among neutropenic patients, sepsis is a frequent cause of ICU admission, and its epidemiology is well described, but data on infection acquired during the ICU stay (ICU-AI) are lacking. AIM: We aim to describe, using a large nationwide cohort study, the incidence of ICU-AI for neutropenic patients in a large network of French intensive care units (ICUs). METHODS: This study was conducted using the healthcare-associated infection surveillance cohort “REA-REZO” involving 265 participating ICUs. All patients admitted to a participating ICU from 1st January 2018 to 31th December 2023, for more than 48 h were eligible. The primary endpoint was the rate of ICU-AI. A matched analysis was conducted using non-parsimonious regression model to compare neutropenic and non-neutropenic patients. FINDINGS: Matching process resulted in well-balanced 7545 patients’ pairs. ICU-AI incidence rate was 14.9 versus 13.0 AI per 1000 patients days in the neutropenic group vs non-neutropenic group (Incidence Rate Ratio [IRR] = 1.15 [1.05, 1.25] p = 0.002) with higher incidence rate for bloodstream infection (BSI) (p < 0.001) but comparable incidences rates of pneumonia (p = 0.503) and central-line associated BSI (p = 0.100). There were less enterobacterales among ICU-AI of the neutropenic group (33.8% vs 45.4%, p < 0.001), but higher rate of coagulase negative Staphylococcus (12.0% vs 5.2%, p < 0.001), Enterococcus spp, (8.9% vs 6.0%, p = 0.015) and Candida spp. (10.4% vs 6.2%, p = 0.001). Rates of ICU-AI involving multidrug resistant micro-organisms did not differed, neither did the rate of ICU-AI involving non fermenting Gram-negative bacilli. CONCLUSION: Neutropenic patients had higher ICU-AI incidence as compared with non-neutropenic patients, specifically through an increase of BSI incidence. Microbiology differs between neutropenic patients and non-neutropenic patients with no difference in multidrug resistant microorganism involvement.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- ICU-acquired infection in neutropenic patients
- Date Crossref
- 17/03/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Neutropenia and Cancer InfectionsNosocomial Infections in ICUSepsis Diagnosis and Treatment