Fatal Renal Mucormycosis Following Pediatric Deceased Donor Kidney Transplantation in a High‐Risk Recipient: A Case Report
Rattachement africain : Afrique du Sud. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Mucormycosis is a rare but devastating opportunistic fungal infection in immunocompromised hosts with particularly high morbidity and mortality in solid organ transplant recipients. Pediatric cases are exceedingly rare, and outcomes are often fatal. CASE PRESENTATION: We report a case of a 13-year-old girl on chronic peritoneal dialysis who received a deceased donor kidney transplant. She was at immunological risk due to a positive virtual crossmatch. Induction therapy included antithymocyte globulin and methylprednisolone, followed by a maintenance immunosuppressive regimen of prednisone, mycophenolate mofetil, and tacrolimus. Post-transplant, she developed early graft dysfunction, anuria, and hemodynamic instability. A graft biopsy showed acute tubular necrosis and C4d positivity prompting plasma exchange for suspected antibody-mediated rejection. Graft explant on day nine revealed angio-invasive mucormycosis due to Rhizopus arrhizus. The rapid onset suggested the infection may have been acquired from the donor. Despite antifungal therapy, she suffered from recurrent arterial pseudoaneurysms in the surgical bed. She died 91 days post-transplant from a ruptured iliac artery mycotic aneurysm. CONCLUSION: This case highlights the challenges in diagnosing and managing mucormycosis in pediatric kidney transplant recipients. A high index of suspicion together with early recognition, aggressive surgical management, and appropriate antifungal treatment is essential. Donor derived fungal infections should be considered in cases of early onset disease. Unfortunately, outcomes remain poor.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Fatal Renal Mucormycosis Following Pediatric Deceased Donor Kidney Transplantation in a High‐Risk Recipient: A Case Report
- Date Crossref
- 01/03/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of the Witwatersrand Nelson Mandela Children's Hospital University of the Witwatersrand, Afrique du Sud (code pays fourni par la source)Université ou école supérieure
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Nelson Mandela Academic Hospital Afrique du Sud (code pays fourni par la source)Établissement de santé
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National Health Laboratory Service Afrique du Sud (code pays fourni par la source)Organisme public
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Johannesburg Hospital Johannesburg Hospital, Afrique du Sud (code pays fourni par la source)Établissement de santé
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Chris Hani Baragwanath Hospital Afrique du Sud (code pays fourni par la source)Établissement de santé
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Faculty of Health Sciences University of Witwatersrand Johannesburg South Africa Department of Clinical Microbiology and Infectious Diseases Witwatersrand, Afrique du Sud (pays nommé en fin d’affiliation)Université ou école supérieure
Nelson Mandela Children's Hospital — University of the Witwatersrand (University of the Witwatersrand, Afrique du Sud), Nelson Mandela Academic Hospital (Afrique du Sud) et National Health Laboratory Service (Afrique du Sud), avec 3 autres affiliations. Pays d’affiliation : Afrique du Sud.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.