Single Nucleus RNA sequencing (snRNA-seq) Processed Datasets from Rat Hippocampus in an Alzheimer's Pretangle Tau Model

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Processed Single-Nucleus RNA-seq Data of Rat Hippocampus (Pretangle Tau Model) This dataset provides processed single-nucleus RNA sequencing (snRNA-seq) data from the hippocampus of *Rattus norvegicus* in a pretangle tau model of Alzheimer’s disease. The data have been pre-processed and curated for downstream analyses such as clustering, differential gene expression (DEG), and functional enrichment. All code used for processing and downstream analyses is available here: https://github.com/ziahasanz/hippocampus_paper/ Filename Description hippo_allcelltypesData.h5ad Processed AnnData object containing all hippocampal cell types with integrated expression and metadata. ex_data.h5ad Processed AnnData object of excitatory neurons. in_data.h5ad Processed AnnData object of inhibitory neurons. ex_DEGs.zip Differentially expressed genes for excitatory neuron clusters across groups. in_DEGs.zip Differentially expressed genes for inhibitory neuron cluster across groups. OligoAstroMicro_DEGs.zip Differentially expressed genes for oligodendrocytes, astrocytes, and microglia. ex_G0_DEGs_c012.zip Differentially expressed genes of excitatory subclusters (C0–2) for GO analysis. in_G0_DEGs_c1235.zip Differentially expressed genes of excitatory subclusters (C1,2,3,5) for GO analysis. ex_GO_BP.csv Gene Ontology (Biological Process) enrichment results for excitatory neurons. OligoAstroMicro_GO_BP.csv GO enrichment results for oligodendrocytes, astrocytes, and microglia.

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