Genetic Syndromes Do Not Affect Survival but Increase Morbidity in Neonates with Symptomatic Tetralogy of Fallot
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: To assess associations between the presence of genetic diagnoses and survival and morbidity of patients with symptomatic tetralogy of Fallot (sTOF) requiring neonatal intervention. STUDY DESIGN: We performed an analysis of a multicenter, retrospective study of sTOF patients from 2005 to 2017 from the Congenital Cardiac Research Collaborative. The primary outcome was transplant-free survival, evaluated by Cox proportional hazards regression modeling, adjusted for center, repair strategy, anatomical diagnosis, prematurity, and invasive ventilation before intervention. Genetic diagnoses were retrospectively collected from hospital records. RESULTS: The study group included 572 neonates with sTOF, of whom 151 (26.4%) had an identifiable genetic diagnosis, including 22q11 deletion (n = 63, 41.7%), trisomy 21 (n = 28, 18.5%), and other genetic diagnoses (n = 60, 39.7%). At a median follow-up of 4.12 (1.53, 7.47) years, there was no significantly increased hazard ratio of death in patients with a genetic diagnosis (adjusted hazard ratio 1.71 [95% CI 0.96-3.07], P = .07). However, patients with a genetic diagnosis had longer median intensive care unit and total hospital stays ([13 vs 9 days, P < .001] and [32.5 vs 24 days, P < .001], respectively) and were more likely to be discharged with feeding tubes (OR 2.1 [95% CI 1.31-3.37], P = .002). CONCLUSIONS: Neonates with sTOF with a genetic diagnosis had no significant survival difference to those without but did have a higher risk for other hospital morbidities, including longer admissions and the need for feeding tubes. Genetic testing in this population can inform clinicians and families regarding these important considerations within this congenital heart disease population.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Genetic Syndromes Do Not Affect Survival but Increase Morbidity in Neonates with Symptomatic Tetralogy of Fallot
- Date Crossref
- 01/07/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Columbia University Irving Medical Center pays non établi dans la noticeÉtablissement de santé
-
Children's Hospital of Pittsburgh pays non établi dans la noticeÉtablissement de santé
-
Washington University in St. Louis pays non établi dans la noticeUniversité ou école supérieure
-
Kaiser Permanente pays non établi dans la noticeOrganisation à but non lucratif
-
West Virginia University Hospitals pays non établi dans la noticeÉtablissement de santé
-
Vanderbilt University Medical Center pays non établi dans la noticeÉtablissement de santé
-
C. S. Mott Children's Hospital pays non établi dans la noticeÉtablissement de santé
-
Children's Hospital of Philadelphia pays non établi dans la noticeOrganisme public
-
University of Alabama at Birmingham pays non établi dans la noticeUniversité ou école supérieure
-
Cincinnati Children's Hospital Medical Center pays non établi dans la noticeÉtablissement de santé
-
University of California San Francisco Medical Center pays non établi dans la noticeÉtablissement de santé
-
Baylor College of Medicine pays non établi dans la noticeUniversité ou école supérieure
Columbia University Irving Medical Center, Children's Hospital of Pittsburgh et Washington University in St. Louis, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.