Antithyroid drug treatment in pregnancy: a first report from the Danish PRETHYR multicenter study
Rattachement africain : dk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
CONTEXT: Hyperthyroidism caused by Graves' disease (GD) should be treated in pregnancy to prevent maternal and fetal complications; however, side effects observed with antithyroid drugs (ATDs) may complicate current clinical management. OBJECTIVE: To investigate current treatment practices for hyperthyroidism during pregnancy in Denmark and the characteristics of women receiving ATDs. METHODS: The Danish multicenter study PRETHYR (Pregnancy Investigations on Thyroid Disease) included women with GD and women treated with ATDs in pregnancy. Maternal characteristics, preconception measurements of TSH, total T3, and TSH-receptor antibodies, and information on the clinical management and treatment before and during pregnancy, were obtained through patient questionnaires and review of the medical record. RESULTS: Of the 121 women included, 97.5% had GD. Among the 102 women with known thyroid disease preconceptionally and no prior definitive treatment, 58.8% (n = 60) received ATDs in pregnancy. These women were more often managed by endocrinologist at conception, had lower preconception TSH, and higher total T3 and TSH-receptor antibodies compared to women not treated with ATDs. Treatment was predominantly confined to the first half of the first trimester and generally discontinued by the second or third trimester. Before conception, 59.1% of women treated with methimazole were switched to propylthiouracil, and 10.7% were switched from propylthiouracil to methimazole. CONCLUSION: This is the first report from a multicenter study on pregnant women with GD and women treated with ATDs during pregnancy. The results provide insight into the current clinical treatment practices of hyperthyroidism in Denmark.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Antithyroid drug treatment in pregnancy: a first report from the Danish PRETHYR multicenter study
- Date Crossref
- 06/03/2026
- Éditeur
- The Endocrine Society
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Aalborg University Hospital Department of Clinical Biochemistry pays non établi dans la noticeÉtablissement de santé
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Aalborg University pays non établi dans la noticeUniversité ou école supérieure
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Aarhus University Hospital Department of Endocrinology pays non établi dans la noticeÉtablissement de santé
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University of Southern Denmark Institute of Clinical Research pays non établi dans la noticeUniversité ou école supérieure
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Odense University Hospital Department of Endocrinology pays non établi dans la noticeOrganisme public
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Zealand University Hospital Department of Endocrinology pays non établi dans la noticeÉtablissement de santé
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University of Copenhagen pays non établi dans la noticeUniversité ou école supérieure
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Herlev Hospital pays non établi dans la noticeÉtablissement de santé
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Gentofte Hospital Department of Internal Medicine pays non établi dans la noticeÉtablissement de santé
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IT University of Copenhagen pays non établi dans la noticeUniversité ou école supérieure
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Copenhagen University Hospital Department of Clinical Medicine pays non établi dans la noticeÉtablissement de santé
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Rigshospitalet pays non établi dans la noticeÉtablissement de santé
Department of Clinical Biochemistry — Aalborg University Hospital, Aalborg University et Department of Endocrinology — Aarhus University Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.