Personalized treatment with Fresh Frozen Plasma for the pro-inflammatory septic phenotype characterized by refractory shock, hemodynamic incoherence, and endothelial damage. A proof of concept

Résumé fourni par la source

This prospective, monocentric observational study evaluated the association between fresh frozen plasma (FFP) administration and clinical outcomes in 30 patients with catecholamine-resistant septic shock. Despite the FFP group presenting with higher baseline severity—characterized by elevated lactate levels and greater norepinephrine requirements—longitudinal analysis revealed that vasoactive support decreased in both groups over time, with no significant differences in norepinephrine doses by 48 and 72 hours. Ultimately, while FFP demonstrated an acceptable safety profile and early hemodynamic changes, it did not significantly reduce ICU mortality or mechanical ventilation requirements compared with conventional therapy. These findings suggest that while FFP may have modulatory potential, its clinical efficacy remains hypothesis-generating and warrants further investigation through larger, randomized controlled trials.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.