Real-Life Clinico-pathological Profile of Neuroendocrine Tumor (NET): An Experience from a Tertiary Care Hospital in Mumbai

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Aims and Objectives: To study real-world clinical-pathological profile of neuroendocrine tumors (NETs) at a tertiary care hospital. Materials and Methods: This is a retrospective observational study of all patients with NETs registered at tertiary care cancer institute from 2016 to 2024. A total of 27 patients’ data were collected. Clinicopathological features of all these 27 patients were studied and analyzed. Results: The median age was 53 years (29–79 years) with male preponderance (male: 70.3%, N = 19). Diagnosis was made by either biopsy ( n : 21) or pos- surgery with histopathological diagnosis at time of surgery. 18 out of 27 patients had histology grade 1 followed by grade 2 seen in 7 patients and 2 patients had grade 3. The most common primary site of origin was small intestine (10/27 = 37%), followed by pancreas (7/27), lung (3/27), gastric (2/27), and other included liver, ovary appendix and mediastinal mass. The most common presenting symptom was weight loss, followed by pain. 11 out of 27 were metastatic at presentation). Long acting Octreotide analogue was the most common primary therapy (13/27), followed by Chemotherapy (9/27) followed by PRRT therapy (4/27), PRRT was used as second-line treatment in all 4 patients either due to disease progression on treatment or relapse, followed by watchful monitoring. Conclusion: The clinicopathological profile of NETs in the Indian population differs from Western countries. Patients present with metastatic disease, GI NET being more common, diverse clinical profile, thus represents a need for creating awareness among patients and medical fraternity and formulating Indian guidelines for optimized treatment. Publication History Article published online: 20 February 2026 © 2026. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/) Thieme Medical and Scientific Publishers Pvt. Ltd. A-12, 2nd Floor, Sector 2, Noida-201301 UP, India

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