Lipidomic dataset of MDA-MB-231 human breast cancer cells treated with diacylglycerol acyltransferase (DGAT) inhibitors and docosahexaenoic acid (DHA)

Résumé fourni par la source

Lipid droplets (LDs) are dynamic fat storage organelles involved in fatty acid metabolism. By storing polyunsaturated fatty acids (PUFAs) in the form of neutral lipids, LDs can either mitigate or exacerbate lipotoxic damage. However, their role in regulating cellular fatty acid distribution, membrane unsaturation, and ferroptosis susceptibility remains poorly understood. To explore how LD turnover modulates membrane lipid composition and ferroptosis sensitivity in cancer cells exposed to exogenous PUFAs, MDA-MB-231 human triple-negative breast cancer cells were supplemented with non-lethal concentrations of exogenous docosahexaenoic acid (DHA) and treated with inhibitors of diacylglycerol acyltransferases (DGAT) 1 and 2. Untargeted lipidomic analysis revealed substantial lipidome remodeling with 302 significantly altered lipids in response to DGAT inhibition, DHA supplementation, or combined treatment.

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