Exploring selenium nanoparticles synthesized using pyrazole-based derivatives: Synthesis and in vitro biological evaluation as potential anti-diabetic and anti-alzheimer's agents

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Selenium nanoparticles have a wide range of applications in various fields, especially in the medical field. In this context, this manuscript aims to prepare and characterize selenium nanoparticles synthesized using pyrazole-based derivatives and investigate their potential biological activity as anti-diabetic and anti-Alzheimer's agents. The two selenium nanoparticles, Se-NPs+Py1 and Se-NPs+Py2, were characterized by a Fourier transform infrared (FTIR) spectrophotometer, ultraviolet-visible (UV-Vis) spectroscopy, and transmission electron microscopy (TEM). The results of in vitro biological evaluation show that the Se-NPs+Py1 (α-amylase = 49.98 ± 0.22% and α-glucosidase = 44.23 ± 0.22%) and Se-NPs+Py2 (α-amylase = 54.99 ± 0.27% and α-glucosidase = 49.24 ± 0.27%) possess potent activity against the α-amylase and α-glucosidase enzymes, as well as the acetylcholinesterase enzyme (Se-NPs+Py1 = 38.48 ± 0.21% and Se-NPs+Py2 = 38.06 ± 0.21%), more than the pyrazole-based derivatives Py1 (α-amylase = 37.62 ± 0.18%, α-glucosidase = 31.87 ± 0.18%, and acetylcholinesterase = 36.65 ± 0.20%) and Py2 (α-amylase = 41.62 ± 0.21%, α-glucosidase = 35.87 ± 0.21%, and acetylcholinesterase = 36.25 ± 0.20%). KEY WORDS: Nanotechnology, Nanoparticles synthesized, Transmission electron microscopy, α-Glucosidase enzyme, Native electrophoretic patterns Bull. Chem. Soc. Ethiop. 2026, 40(4), 879-892. DOI: https://dx.doi.org/10.4314/bcse.v40i4.11