Proportion of Non-Alcoholic Fatty Liver Disease and Its Risk Factors among Sedentary Workers of a Tertiary Care Centre: Camp-Based Findings

Résumé fourni par la source

Background: A growing public health problem is non-alcoholic fatty liver disease (NAFLD), especially in sedentary workers. The purpose of this study was to estimate the proportion of sedentary tertiary care hospital staff who had NAFLD and related risk factors. Methods: In North India, a tertiary care facility held a cross-sectional screening camp for sedentary employees. Fibrosis was evaluated using liver stiffness measurement (LSM), while steatosis was evaluated using the ultrasound attenuation parameter (UAP). Data on socio demographics, lifestyle, and comorbidities were collected by a self-designed questionnaire filled by the investigator. All participants were on fasting before testing. Results: Among 211 participants (83.4% male; mean age 34.5 ± 7.11 years), advanced fibrosis (F3–F4) was detected in 10.4% and severe steatosis (S3) in 26.5%. Steatosis grade was significantly associated with age and gender. On multivariable analysis, age independently predicted severe steatosis (30–39 years: AOR 2.76, p = 0.013; ?40 years: AOR 4.60, p = 0.009), while gender and other factors were not significant. UAP-based steatosis grades were associated with LSM-based fibrosis stages (p = 0.006). No missing data were observed. Conclusions: A substantial burden of NAFLD-related fibrosis and steatosis was detected among sedentary workers. Workplace-based screening and lifestyle interventions are recommended.

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