Évaluation du devenir cognitif après un accident vasculaire cérébelleux et corrélations anatomo-cliniques

Le résumé fourni par la source

The cerebellum is now acknowledged as being involved in cognitive and emotional functions, particularly executive functions, attention, working memory, language, and social cognition. This led to the description of the Cerebellar Cognitive Affective Syndrome (CCAS), first defined by Schmahmann in 1998. However, its contribution has remained poorly explored in the context of vascular lesions following cerebellar stroke. The aim of this study was to enhance screening and management of patients at risk of neuropsychological sequelae after cerebellar stroke. Our primary objective was to assess the frequency of cognitive and behavioral impairments six months after an isolated cerebellar stroke. The most discriminant performances were found in executive functions, processing speed, and language, which were combined into a global three-domain cognitive score. Significant discriminant performances were also observed for the inactivity score (ISDC). We showed that the global cognitive score correlated with reduced lobular thickness in the posterolateral regions (Crus I, Crus II, lobule VIIIA, lobule VIIIB, lobule VI) on MRI. VLSM analysis further highlighted a minimal left posterolateral cerebellar cluster (Lob VI–Crus I/II–VIIIA/B). Altogether, these findings are consistent with the existing literature. This study therefore confirms the contribution of the cerebellum to cognitive and behavioral functions beyond its traditional motor role, and will help improve understanding and management of cognitive and behavioral disorders following isolated cerebellar strokes.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.