Low Serum sRAGE and MASLD Are Associated and Share a Similar Gut Microbiota Profile: A Prospective and Cross‐Sectional Analysis
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Le résumé fourni par la source
BACKGROUND/AIMS: The pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) is multifactorial, with evidence suggesting a protective role for the soluble receptor for advanced glycation end-products (sRAGE). While gut microbiota dysbiosis and MASLD have been linked, evidence of their association with sRAGE remains limited. We aimed to test the prospective association between serum sRAGE levels and MASLD and to explore associated patterns of gut microbiota composition. METHODS: A prospective cohort study assessed serum sRAGE levels and MASLD at two time points, with new-onset or persistence of MASLD evaluated by ultrasonography or controlled attenuation parameter. A cross-sectional analysis was performed on a sub-sample with gut microbiota measurements using 16S rRNA sequencing (V3-V4, Illumina MiSeq). RESULTS: Among 289 subjects in the prospective analysis (mean follow-up: 6.67 ± 0.73 years, mean age: 58.54 ± 6.54 years, 57.8% men), low sRAGE levels were associated with 2.22-fold greater odds of new-onset/persistent MASLD (95% CI 1.15-4.26, p = 0.017), with a dose-response association across sRAGE tertiles. The cross-sectional analysis with a subsample of 136 subjects showed significant α- and β-diversity differences between MASLD and non-MASLD groups. Moreover, β-diversity variation across sRAGE groups resembled that observed between the MASLD groups. Shared taxa linked to low sRAGE levels and MASLD included Streptococcaceae, Enterobacteriaceae, Streptococcus, Dorea, and Klebsiella. Non-MASLD and high sRAGE levels were associated with Christensenellaceae, Akkermansiaceae, Christensenellaceae R-7 group and Akkermansia. CONCLUSIONS: Low sRAGE levels are associated with higher odds of MASLD. MASLD and low sRAGE levels share a similar gut microbiota signature, suggesting a potential biological link that warrants further investigation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Low Serum <scp>sRAGE</scp> and <scp>MASLD</scp> Are Associated and Share a Similar Gut Microbiota Profile: A Prospective and Cross‐Sectional Analysis
- Date Crossref
- 12/02/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tel Aviv Sourasky Medical Center pays non établi dans la noticeÉtablissement de santé
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University of Haifa Bioinformatics Services Unit pays non établi dans la noticeUniversité ou école supérieure
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Hebrew University of Jerusalem pays non établi dans la noticeUniversité ou école supérieure
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Tel Aviv University pays non établi dans la noticeUniversité ou école supérieure
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Department of Gastroenterology Tel Aviv Medical Center Tel Aviv Israel pays non établi dans la noticeÉtablissement de santé
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School of Public Health Department of Health Promotion pays non établi dans la noticeUniversité ou école supérieure
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RHS Faculty of Agriculture Institute of Biochemistry pays non établi dans la noticeUniversité ou école supérieure
Tel Aviv Sourasky Medical Center, Bioinformatics Services Unit — University of Haifa et Hebrew University of Jerusalem, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.