Depression and anxiety in interstitial lung disease: a systematic review, meta-analysis and Mendelian randomization
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Le résumé fourni par la source
OBJECTIVE: To investigate the prevalence of depression and anxiety in interstitial lung disease (ILD) and reveal whether ILD is causally associated with depression and anxiety via Mendelian randomization (MR). METHODS: Eligible studies were identified and selected from Web of Science, PubMed and Scopus. The pooled prevalence of depression and anxiety in ILD, as well as the clinical characteristics of ILD with depression or anxiety, were assessed. Sensitivity analyses, subgroup analyses and meta-regression were applied for heterogeneity assessments. Data of MR analysis were derived from the UK biobank and Finngen cohort, and the inverse variance weighting approach was selected as the main approach for causality evaluation. RESULTS: = 98%), respectively. There was no significant difference in the prevalence of depression (p = 0.41) or anxiety (p = 0.39) across various subtypes of ILD. ILD patients with depression had a lower BMI (MD -2.11, 95% CI -3.82, -0.41, p = 0.02). Results of MR analysis revealed no causal associations for either the ILD-depression (OR 1.000, 95% CI 0.997, 1.003; p = 0.962) or the ILD-anxiety (OR 1.000, 95% CI 0.998, 1.002; p = 0.888) relationships. CONCLUSION: Although the prevalence of depression and anxiety were high in patients with ILD, no causal relationship was observed. Future studies are needed to investigate the intricate association between ILD and mental health.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Depression and anxiety in interstitial lung disease: a systematic review, meta-analysis and Mendelian randomization
- Date Crossref
- 12/02/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Sichuan University Department of Pulmonary and Critical Care Medicine pays non établi dans la noticeUniversité ou école supérieure
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West China Hospital of Sichuan University pays non établi dans la noticeÉtablissement de santé
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West China Medical Center of Sichuan University pays non établi dans la noticeÉtablissement de santé
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Public Health Clinical Center of Chengdu pays non établi dans la noticeÉtablissement de santé
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Sichuan Public Health General Clinical Center pays non établi dans la noticeÉtablissement de santé
Department of Pulmonary and Critical Care Medicine — Sichuan University, West China Hospital of Sichuan University et West China Medical Center of Sichuan University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.