Effects of Walnut Consumption on Blood Lipid Profile and Apolipoproteins in Adults: A GRADE ‐Assessed Systematic Review and Dose–Response Meta‐Analysis of 49 Randomized Controlled Trials
Rattachement africain : ir, ua. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
ABSTRACT Walnuts ( Juglans regia L.) are rich in polyunsaturated fatty acids (PUFAs), fiber, and bioactive compounds that may positively affect lipid metabolism. Although several clinical trials have examined their impact on the lipid profile, results have been inconsistent, and evidence regarding their effects on apolipoproteins is limited. This meta‐analysis aims to systematically assess the impact of walnut consumption on blood lipid profile and apolipoproteins in adults. A comprehensive search of major databases was conducted up to August 2025 to find relevant randomized controlled trials (RCTs) evaluating the effects of walnut intake on triglycerides (TG), total cholesterol (TC), low‐ and high‐density lipoprotein cholesterol (LDL‐C and HDL‐C), apolipoproteins A1 and B (Apo‐A1 and Apo‐B). Pooled effect sizes were estimated using a random‐effects model. The pooled analysis of 49 RCTs (57 effect sizes; 4611 participants) showed that Walnut consumption significantly reduced and TG (WMD: −6.24 mg/dL, 95% CI: [−9.49, −2.99], p < 0.001), TC (WMD: −6.39 mg/dL, 95% CI: [−8.54, −4.23], p < 0.001), and LDL‐C (WMD: −5.68 mg/dL; 95% CI: [−7,89, −3.47], p < 0.001), while no significant effect was observed on HDL‐C (WMD: 0.71 mg/dL, 95% CI: [−0.24, 1.68], p = 0.145), Apo‐A1 (WMD: 0.0, 95% CI: [−0.01, 0.00], p = 0.573), or Apo‐B (WMD: 0.1, 95% CI: [−0.02, 0.05], p = 0.462). However, subgroup analyses indicated significant reductions in Apo‐B at higher walnut doses (> 50 g/day) and increases in HDL‐C in the low‐dose intervention (< 50 g/day). In conclusion, walnut supplementation improves the lipid profile by significantly lowering TC, LDL‐C, and TG levels. However, effects on HDL‐C and apolipoproteins remain inconclusive. These findings support the incorporation of walnuts as part of a heart‐healthy dietary pattern.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Effects of Walnut Consumption on Blood Lipid Profile and Apolipoproteins in Adults: A <scp>GRADE</scp> ‐Assessed Systematic Review and Dose–Response Meta‐Analysis of 49 Randomized Controlled Trials
- Date Crossref
- 01/02/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Kerman University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Ahvaz Jundishapur University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Bogomolets National Medical University pays non établi dans la noticeUniversité ou école supérieure
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Shahid Beheshti University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Iran University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Shiraz University of Medical Sciences Department of Pharmacognosy pays non établi dans la noticeUniversité ou école supérieure
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Yasuj University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Medicine Ahvaz Jundishapur University of Medical Science Ahvaz Iran pays non établi dans la noticeUniversité ou école supérieure
Kerman University of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences et Bogomolets National Medical University, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.