Green synthesis of magnesium oxide nanoparticles using Nigella sativa seed extract: characterization, in vitro antioxidant activities, and wound healing efficacy in streptozotocin-induced diabetic rats

Résumé fourni par la source

wound healing efficacy was examined in streptozotocin-induced diabetic Wistar rats. An excision wound model was established, and MgO-NPs were topically applied daily. Wound contraction was monitored over 17 days, and biochemical parameters such as C-reactive protein, lipid peroxidation, advanced oxidation protein products, GSH, non-protein thiols, and antioxidant enzyme activities (CAT, SOD, GPx) were measured in serum and tissue samples. As a result, a significant acceleration of wound healing was observed in diabetic rats treated with MgO-NPs, as evidenced by a reduction in wound diameter and decreased CRP levels (-22%) compared to the control group, as well as a modulation of enzymatic and non-enzymatic antioxidants, which was further confirmed by histological analysis. Considering our outcomes, MgO-NPs could be used as an effective dressing material as well as a tissue regrowth scaffold for diabetic wound therapy.

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