Anti-inflammatory Amide–Alkaloid Dimers from the Roots of Piper nigrum L.: Feature-Guided Discovery and Photocatalytic Synthesis

Le résumé fourni par la source

As a traditional medicinal-food ingredient, pepper roots were investigated for bioactive dimeric amide alkaloids. Eighteen pairs of novel anti-inflammatory dimeric amide alkaloids ( 1a / 1b – 18a / 18b ) and two known analogues ( 19 and 20 ) were isolated under the guidance of a feature-guided molecular networking (FGMN) strategy, with their structures established by extensive spectroscopic analyses and X-ray diffraction. A visible light photocatalytic method enabled the sustainable synthesis of the dimeric scaffold directly from piperine, a key component of Piper nigrum . In vitro assays demonstrated significant inhibition of NO production in a LPS-induced RAW 264.7 macrophage model. Additionally, dimeric amide alkaloid 21 significantly alleviated skin inflammation, demonstrating bioactivity from a food-derived compound. Overall, this study highlights the potential of P. nigrum roots as a sustainable source of functional alkaloids and establishes a photocatalytic route to skin-health-promoting food ingredients, advancing the valorization of piperine in functional foods.

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