Children and adolescents: Respiratory infection and long-term effects longitudinal study (CARE Study): Study protocol
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Le résumé fourni par la source
BACKGROUND: The effects of SARS-Cov-2 infection can extend beyond the acute phase of the illness, often described as Long COVID, post-COVID condition (PCC) or Post-acute sequelae of COVID (PASC). Post-acute sequelae (PAS) are also likely to be a problem for a small proportion of children and adolescents following influenza infection. However, there is no comprehensive ongoing data collection in Australian children and adolescents, and global data on both PCC during the SARS-Cov-2 Omicron variant period and PAS following influenza is limited. AIM: This study aims to determine the cumulative incidence of PCC in Australian children and adolescents five years after the start of the COVID-19 pandemic. Secondary aims include identifying the cumulative incidence of PAS in children and adolescents following influenza infection. METHODS: This longitudinal cohort study will recruit children and adolescents aged 0-18 years in South Australia who tested positive for SARS-Cov-2 or influenza in the previous 2 months. Following consent, participants will complete an online baseline survey and then at 3, 6, and 12 months post-infection. The survey has been adapted from the International Severe Acute Respiratory and Emerging Infection Consortium (ISARIC) Paediatric COVID-19 follow-up survey. The survey includes validated assessment tools such as the Pediatric Quality of Life Inventory (PedsQL), Multidimensional Fatigue Scale, and the Malmö Postural Orthostatic Tachycardia Syndrome (POTS) Score questionnaire. PCC following COVID-19 and PAS following influenza infection will be identified according to an adapted World Health Organization definition of PCC in children and adolescents. DISCUSSION: This study addresses gaps in understanding PCC and PAS following influenza in children and adolescents during Omicron circulation. Whilst it is no longer feasible to prospectively compare post-acute sequelae in children and adolescents who have never had COVID-19, this design allows a comparison with another common viral infection, influenza, informing clinical management of children post-infection.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Children and adolescents: Respiratory infection and long-term effects longitudinal study (CARE Study): Study protocol
- Date Crossref
- 05/02/2026
- Éditeur
- Public Library of Science (PLoS)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Women's and Children's Hospital Infectious Disease Department pays non établi dans la noticeÉtablissement de santé
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Women's and Children's Health Network pays non établi dans la noticeÉtablissement de santé
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The University of Adelaide Adelaide Medical School and Robinson Research Institute pays non établi dans la noticeUniversité ou école supérieure
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SA Health pays non établi dans la noticeOrganisme public
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South Australian Health and Medical Research Institute Women and Kids Theme pays non établi dans la noticeÉtablissement de santé
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The University of Sydney Sydney Medical School pays non établi dans la noticeUniversité ou école supérieure
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Children's Hospital at Westmead pays non établi dans la noticeÉtablissement de santé
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UNSW Sydney pays non établi dans la noticeUniversité ou école supérieure
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Sydney Children's Hospital Department of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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University Department of Paediatrics pays non établi dans la noticeUniversité ou école supérieure
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Communicable Disease Control Branch pays non établi dans la noticeInstitution
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School of Public Health pays non établi dans la noticeUniversité ou école supérieure
Infectious Disease Department — Women's and Children's Hospital, Women's and Children's Health Network et Adelaide Medical School and Robinson Research Institute — The University of Adelaide, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.