Laser photobiomodulation enhances cell viability and regenerative gene expression in oxidative-stressed muscle cells
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Le résumé fourni par la source
PURPOSE: This study aimed to evaluate the effects of laser photobiomodulation therapy (LPT) on muscle cells subjected to oxidative stress. The primary objective was to determine whether LPT could preserve cell viability and modulate the expression of genes associated with muscle regeneration, specifically MyoD and myogenin, as well as the pro-inflammatory cytokine IL-6. Methods: C2C12 myoblasts were cultured and exposed to oxidative stress using hydrogen peroxide (H₂O₂) at a concentration of 50 µM for 1 h. Cells were then irradiated with LPT at wavelengths of 660–808 nm with fluences of 3, 5, and 10 J, applied either before (PRE-OS) or after (POST-OS) oxidative stress induction. Cell viability was assessed by the MTT assay, and gene expression was quantified using RT-qPCR. Results: Oxidative stress significantly reduced cell viability. LPT applied prior to OS with 660 nm (3 J) and 808 nm (3 and 10 J) attenuated this reduction. Notably, 10 J at 808 nm (PRE-OS) increased viability beyond control levels and markedly upregulated MyoD expression. Myogenin expression was also observed under 10 J PRE-OS conditions, while IL-6 expression was detected with 5 J at both wavelengths in PRE- and POST-OS groups. Conclusion: LPT demonstrated protective and regenerative effects on myoblasts under oxidative stress, preserving viability and enhancing regenerative gene expression. These findings support the potential of LPT as a therapeutic strategy for muscle injuries and disorders associated with oxidative stress.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Laser photobiomodulation enhances cell viability and regenerative gene expression in oxidative-stressed muscle cells
- Date Crossref
- 05/02/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade Norte do Paraná pays non établi dans la noticeUniversité ou école supérieure
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Universidade Evangelica de Goiás pays non établi dans la noticeUniversité ou école supérieure
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Universidade Estadual de Goiás pays non établi dans la noticeUniversité ou école supérieure
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UNIFIO University Center pays non établi dans la noticeUniversité ou école supérieure
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University Pitagoras Unopar Anhanguera Graduate Program Associated in Rehabilitation Science UEL/UNOPAR pays non établi dans la noticeUniversité ou école supérieure
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Evangelical University of Goias Graduate Program in Human Movement and Rehabilitation pays non établi dans la noticeUniversité ou école supérieure
Universidade Norte do Paraná, Universidade Evangelica de Goiás et Universidade Estadual de Goiás, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.