Single-Nuclei Transcriptomics of Pediatric Anthracycline-Induced Cardiomyopathy

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We performed single-nucleus RNA sequencing on left ventricular myocardium to generate a high-resolution, cell-type–resolved transcriptomic atlas of pediatric anthracycline-induced cardiomyopathy. We integrated data from five female pediatric patients exposed to anthracyclines who progressed to end-stage heart failure requiring transplantation, along with age- and sex-matched pediatric dilated cardiomyopathy patients with end-stage heart failure (3) and non-failing pediatric donors (2). Following quality control and integration, the final dataset comprised 63,826 nuclei from pAICM, 31,973 from pDCM, and 29,190 from pDonors. Unsupervised clustering identified 11 major cardiac cell populations, annotated using established canonical markers. Format: Seurat object.

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