Temporal Trends in Pregnancy Outcomes Among Parents With Type 1 Diabetes: A Nationwide Register‐Based Study

Résumé fourni par la source

OBJECTIVE: To assess temporal trends in outcomes of pregnancies with maternal or paternal type 1 diabetes compared to the general population. DESIGN: Register-based study. SETTING: Denmark. POPULATION: 1 551 893 pregnancies from 1997 to 2021, hereof 5478 with maternal and 8072 with paternal type 1 diabetes. METHODS: Crude and adjusted logistic regression analyses allowing for interaction between diabetes and time compared outcomes of pregnancies with maternal or paternal type 1 diabetes to the general population and evaluated temporal trends over a 25-year period. MAIN OUTCOME MEASURES: Hypertensive disorders of pregnancy, caesarean delivery, preterm delivery (< 37-week gestation), very preterm delivery (< 34-week gestation), large for gestational age (LGA) (birth weight > 90th percentile) and extreme LGA (birth weight > 97.5th percentile). RESULTS: We observed an increasing prevalence of maternal (0.3%-0.4%) and paternal (0.5%-0.6%) diabetes during the study period. From 1997-2001 to 2017-2021, pregnancies with maternal diabetes had decreasing odds of preterm delivery (aOR 0.62, 95% CI 0.51;0.74), very preterm delivery (aOR 0.62, 95% CI 0.44;0.87) and extreme LGA (aOR 0.73, 95% CI 0.61;0.88) but remained associated with higher odds of each considered pregnancy outcome in both first and last period (aOR 3.59-18.86) compared to the general population. Pregnancies exposed to paternal diabetes were comparable to the general population. CONCLUSIONS: Despite a decline in adverse outcomes in pregnancies with maternal type 1 diabetes over the last 25 years, the odds remain greatly increased. These findings support a predominant role of maternal diabetes management rather than parental diabetes genes for pregnancy outcomes.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.