Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors
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Le résumé fourni par la source
Acylation modification plays a crucial role in tumor progression through altering protein homeostasis and localization. However, a comprehensive summary of these processes is lacking. Protein acylation modifications are comprehensively summarized and categorized based on the amino acids that are modified. This review focuses on modifications of the lysine (acetylation, succinylation, crotonylation, malonylation, and glutarylation) and cysteine (myristoylation and palmitoylation) groups. The key enzymes involved in the occurrence and erasure of different modifications, as well as their effects on protein stability, cell localization, and tumor progression, are highlighted. The targeted delivery systems related to acylation modification are summarized, and currently available commercial inhibitors are also reviewed. Finally, acylation modifications with therapeutic potential in Phase I clinical trials are reviewed.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors
- Date Crossref
- 02/02/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
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