Impact of Preoperative Diuretics Treatment on Long-Term Clinical Outcomes After Transcatheter Aortic Valve Implantation
Rattachement africain : jp. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Diuretics are used to relieve congestive symptoms in patients with severe aortic stenosis (AS). However, the effect of preprocedural diuretic treatment on long-term outcomes in AS patients who undergoing transcatheter aortic valve implantation (TAVI) remains unclear. We prospectively enrolled 4,903 consecutive AS patients who underwent TAVI in 7 Japanese hospitals between April 2010 and June 2024 and evaluated the effect of preprocedural diuretics treatment on clinical outcomes. Patients were divided into 2 groups as follows: the Diuretics group, who received diuretic treatment before TAVI (n = 2,073), and the Non-Diuretics group without diuretic treatment (n = 2,830). The median observation period was 2.1 years. The Diuretics group was older and had higher surgical risk scores and more comorbidities, including prior myocardial infarction, atrial fibrillation/flutter, and peripheral artery disease. The Diuretics group included more patients with New York Heart Association (NYHA) classification III/IV, lower left ventricular ejection fraction, and reduced renal function. They had significantly worse all-cause and cardiovascular mortality than those in the Non-Diuretics group (38% versus 26% and 18% versus 10%, respectively; P < 0.001 by log-rank test). After propensity score matching to minimize the influence of confounding factors, preoperative diuretic treatment was associated with worse all-cause mortality (hazard ratio [HR]: 1.29, 95% confidence interval [CI]: 1.06-1.58, P = 0.012) and cardiovascular mortality (HR: 1.61, 95%CI: 1.15-2.26, P = 0.006). Two fifths of AS patients who undergoing TAVI received preoperative diuretics, and those patients had worse all-cause and cardiovascular mortality. Preprocedural diuretic treatment was an independent predictor of all-cause and cardiovascular mortality after TAVI.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Impact of Preoperative Diuretics Treatment on Long-Term Clinical Outcomes After Transcatheter Aortic Valve Implantation
- Date Crossref
- 31/01/2026
- Éditeur
- International Heart Journal (Japanese Heart Journal)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Hirosaki University Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Sakakibara Hospital pays non établi dans la noticeÉtablissement de santé
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Yamagata University Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Juntendo University Department of Cardiovascular Biology and Medicine pays non établi dans la noticeUniversité ou école supérieure
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Mie University Department of Cardiology pays non établi dans la noticeUniversité ou école supérieure
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Kawasaki Hospital pays non établi dans la noticeÉtablissement de santé
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Kawasaki Saiwai Hospital Department of Cardiology pays non établi dans la noticeÉtablissement de santé
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Toho University Division of Cardiovascular Medicine pays non établi dans la noticeUniversité ou école supérieure
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Sakakibara Heart Institute Department of Cardiology pays non établi dans la noticeStructure de recherche
Department of Cardiology — Hirosaki University, Sakakibara Hospital et Department of Cardiology — Yamagata University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.