Abstract WP030: Association of prehospital treatment duration with the efficacy of remote ischemic conditioning in the RESIST trial
Rattachement africain : ca, dk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Remote ischemic conditioning (RIC) initiated in the prehospital setting did not improve functional outcome at 90 days in patients with acute stroke in the RESIST trial. Trials of other neuroprotective therapies have identified the duration of treatment received prior to reperfusion (“dwell time”) as a treatment effect modifier. We examined whether the effects of RIC might be modified by the duration of prehospital treatment that patients received. Methods: In this post-hoc analysis of the RESIST randomized-controlled trial (Clinicaltrials.gov: NCT03481777), we compared outcomes in patients with prehospital stroke symptoms for less than 4 hours, assigned to RIC versus sham, and diagnosed with acute ischemic stroke (AIS) or intracerebral hemorrhage (ICH) – the modified intention-to-treat (mITT) population – stratified by time from randomization to hospital admission (i.e. prehospital treatment duration). The primary outcome was improvement in the ordinal 90-day modified Rankin Scale (mRS) score. Secondary outcomes included 90-day mRS 0-2 and neurological improvement according to the National Institutes of Health Stroke Scale (NIHSS) at 24-hours. Results: Among 902 patients in the mITT population with AIS (n=737) and ICH (n=165), the median randomization-to-admission time was 29.4 minutes (IQR 19.6-39.4 minutes). Upon examining the effect of RIC treatment by pre-hospital treatment duration, there were no significant treatment effects in either the combined mITT, ICH, or AIS groups in any of the transport time groups. Further stratifying patients with AIS based on receipt of reperfusion therapies also revealed no significant differences in RIC efficacy across time. There was no interaction between RIC and pre-hospital treatment duration in relation to 90-day mRS or early NIHSS improvement in the AIS or ICH populations. Conclusion: Longer prehospital treatment duration was not associated with efficacy of RIC in patients with AIS or ICH in the RESIST trial including among AIS patients who received reperfusion therapies, although durations were generally under an hour.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Abstract WP030: Association of prehospital treatment duration with the efficacy of remote ischemic conditioning in the RESIST trial
- Date Crossref
- 01/02/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Calgary pays non établi dans la noticeUniversité ou école supérieure
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Odense University Hospital pays non établi dans la noticeOrganisme public
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Aalborg University Hospital pays non établi dans la noticeÉtablissement de santé
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Central Denmark Region pays non établi dans la noticeOrganisme public
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North Denmark Region pays non établi dans la noticeOrganisme public
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Aarhus University pays non établi dans la noticeUniversité ou école supérieure
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Aarhus University Hospital pays non établi dans la noticeÉtablissement de santé
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AALBORG UNIV HOSPITAL pays non établi dans la noticeUniversité ou école supérieure
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PREHOSPITAL EMERGENCY SERVICES pays non établi dans la noticeÉtablissement de santé
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Regional Hospital Gødstrup pays non établi dans la noticeÉtablissement de santé
University of Calgary, Odense University Hospital et Aalborg University Hospital, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.