Effects of exposure to Fe3O4-PEG-PLGA nanoparticles on the lung of wild type and Nrf2-KO mice

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[Background] Recently, various kinds of bionanomaterials have been developed for the purpose of practical use in medical area or other industrial areas. Fe3O4-PEG-PLGA nanoparticles have been expected to be used in cancer diagnosis or hyperthermia treatment with near infrared radiation. The increase in Fe3O4-PEG-PLGA production might lead to increase in population exposed during manufacturing or using process. However, safety evaluation of Fe3O4-PEG-PLGA nanoparticles is still insufficient. The present study aims to investigate pulmonary effects of Fe3O4-PEG-PLGA nanoparticles and the role of Nrf2. [Methods] Wild type and Nrf2-/- were exposed once to Fe3O4-PEG-PLGA nanoparticles at 0, 10, 30 µg/mouse by pharyngeal aspiration. At 14 days after the exposure, bronchoalveolar lavage BALF was collected to quantify protein level and the number of inflammatory cells in it. After lavage, left lungs were fixed with 4 Also see: https://micro2024.sciencesconf.org/558665/document

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