Blood-flow restriction resistance training improves skeletal muscle mitochondrial capacity and cardiovascular risk factors in type 2 diabetes

Le résumé fourni par la source

Impaired muscle strength and mitochondrial functionality are hallmarks of type 2 diabetes (T2D). Conventional combined resistance/endurance exercise training has limited efficacy to simultaneously improve muscle function and metabolism. We examined whether low-load blood-flow restriction training (BFRT) increases both muscle strength and mitochondrial oxidative capacity in T2D. Over 12 weeks, BFRT and conventional resistance training (CREST) similarly improved muscle strength despite lower workload in BFRT. Uniquely, BFRT enhanced muscle and adipose tissue oxidative capacity and increased muscle mitochondrial content. Transcriptomic profiling revealed more pronounced changes, particularly in angiogenesis-linked pathways, upon BFRT. BFRT also preferentially led to reductions in visceral adipose tissue volume and waist circumference, whereas CREST more effectively decreased subcutaneous adipose tissue volume. Both interventions lowered resting heart rate and diastolic blood pressure. These findings position BFRT as a promising low-load exercising strategy to simultaneously improve mitochondrial oxidative capacity, muscle strength, and body composition in individuals with T2D. • BFRT matches CREST in muscle strength gains despite a markedly lower load • BFRT uniquely enhances skeletal muscle and adipose tissue oxidative capacity • BFRT induces greater transcriptional upregulation of angiogenesis-related pathways • BFRT exclusively reduces visceral adipose tissue volume Trinks et al. showed that blood-flow restriction training (BFRT) provides a low-load alternative to conventional resistance training (CREST), making it well suited for individuals with type 2 diabetes who have musculoskeletal limitations or reduced functional capacity because of promising effects on muscle strength, hypertrophy, mitochondrial capacity, and body composition.

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