Hedgehog pathway disruption alters urothelial differentiation and continence mechanisms in the female mouse lower urinary tract

Résumé fourni par la source

This study identifies disrupted Hh signaling as a key determinant of female bladder and urethral contractility, providing new insights into molecular mechanisms maintaining continence. We observe impaired contractile responses to multiple stimuli, including urethral response to serotonin. In addition, we identify ectopic expression of uroplakin IIIa in urethra of Gli mutant mice, arising after prenatal development. By reducing—but not completely ablating—Hh signaling, we elucidate essential roles of this pathway in determining continence.

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