Abstract Th0055: Smooth Muscle Embryonic Origin Drives Differential Response to Injury in Atherosclerosis

Résumé fourni par la source

Atherosclerosis is the hallmark of multiple vascular diseases including peripheral arterial disease, carotid artery disease, as well as others, and contributes to significant disease burden. Vascular smooth muscle cells (SMCs) throughout the arterial tree arise from different embryonic origins, with each major arterial region representing a unique developmental lineage. Our goal was to investigate if SMCs from different regions (ie different embryonic origins) of the arterial tree exhibited unique gene expression profiles in atherosclerotic versus wildtype mice.

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