Abstract Th0031: The histone deacetylase HDAC11 contributes to diabetic vascular fibrosis

Résumé fourni par la source

The contribution of cardiometabolic disease to atherosclerosis and other cardiovascular pathology is well described, however the mechanisms that control these pathologic changes are unclear. Although the cellular changes contributing to arterial pathology in T2D are more established in endothelial cells and vascular smooth muscle cells, there is less known about the alterations in other cell types, namely fibroblasts. Herein, using unbiased epigenetic arrays and single cell RNA-sequencing (sc-RNA-seq), we define transcriptional differences in fibroblast populations located within the adventitia of diabetic arteries that may contribute to pathologic fibrosis.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.