Osteogenesis-synchronized degradation of Mg2⁺-doped calcium sulfate whisker bone grafts for critical-sized bone defect repair
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Le résumé fourni par la source
Bone defects remain a major clinical challenge in orthopedic and reconstructive surgery. However, conventional inorganic ceramic biomaterials are limited by many problems, such as poor plasticity, limited osteogenic potential, and uncontrolled degradation kinetics, resulting in failing to keep pace with new bones’ healing. Harmonizing biomaterial degradation with osteogenesis thus remains a crucial problem to be addressed in bone tissue engineering. In this study, Mg 2+ -doped calcium sulfate whiskers (MCSW) are synthesized by adopting a high-temperature autoclave method and are fabricated into bone grafting via die-casting molding. Their physicochemical properties, including surface morphology, solution diffusion behavior, mechanical performance, elemental distribution, and Mg 2+ release kinetics, are systematically characterized. Biocompatibility and in vitro osteoinductive potential are evaluated through assaying cell viability and analyzing osteogenic differentiation. Furthermore, the bone grafting is implanted into critical-sized calvarial defect models in Sprague–Dawley rats, and their bones’ regenerative efficacy is assessed by micro-computed tomography (micro-CT) and histological staining. MCSW exhibits many characteristics, including a rough surface, solution-dependent degradation behavior, appropriate mechanical strength, as well as sustained and controlled Mg 2+ release, presenting favorable physicochemical properties with tunable degradation, which shows it is suitable for applying to bone tissue engineering. In vitro studies demonstrate excellent biocompatibility, supporting the survival, proliferation, and osteogenic differentiation of BMSCs, as proved by enhanced alkaline phosphatase (ALP) activity and calcium mineral deposition. More importantly, the in vivo degradation rate of MCSW is well synchronized with osteogenesis, resulting in effective bone regeneration and satisfactory repair of critical-sized defects. This Mg 2+ -doping strategy for calcium sulfate whiskers provides a novel and effective approach to enhance osteogenic activity and achieve tunable degradation in bone tissue engineering biomaterials, thereby showing strong potential for future clinical application.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Osteogenesis-synchronized degradation of Mg2⁺-doped calcium sulfate whisker bone grafts for critical-sized bone defect repair
- Date Crossref
- 23/01/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Yunnan University Spinal Surgery pays non établi dans la noticeUniversité ou école supérieure
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Second People's Hospital of Yunnan Province pays non établi dans la noticeÉtablissement de santé
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Nanchang University pays non établi dans la noticeUniversité ou école supérieure
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Third Affiliated Hospital of Nanchang University pays non établi dans la noticeÉtablissement de santé
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First Affiliated Hospital of Nanchang University pays non établi dans la noticeÉtablissement de santé
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Kunming Medical University pays non établi dans la noticeUniversité ou école supérieure
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Sixth Affiliated Hospital of Kunming Medical University pays non établi dans la noticeÉtablissement de santé
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Kunming University of Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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The First Hospital of Nanchang Department of Orthopedics pays non établi dans la noticeÉtablissement de santé
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Yuxi Jiangchuan District People's Hospital Department of Orthopedics pays non établi dans la noticeÉtablissement de santé
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Faculty of Materials Science and Engineering pays non établi dans la noticeUniversité ou école supérieure
Spinal Surgery — Yunnan University, Second People's Hospital of Yunnan Province et Nanchang University, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.