Calculation of biological age using clinical markers of aging in obese and healthy individuals

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Obesity and aging are global healthcare problems in the modern world. Both processes are characterized by chronic low-grade inflammation, which contributes to an earlier onset of age-related diseases and a decrease in life expectancy. This determines the importance of studying the mechanisms of aging in obese individuals and possible geroprotective measures. Aim. To evaluate the correlation of obesity with changes in biological age in middle-aged people Materials and methods. The retrospective study was conducted at the Hadassah Medical Moscow clinic in the period from January to May 2025. The analysis of anamnestic, anthropometric and laboratory data, as well as the calculation of biological age was performed for patients with class I–II obesity (group 1), control group (group 2). An analysis of the dynamics of changes in biological age on the background of weight loss for obese people with a history of I–II classes (series of clinical cases) was carried out separately. Statistical data processing was performed using the MedCalc program, version 23.1.7. The threshold of significance of the p-value values given in the article is 0.05. Results. The study included 66 participants, which were divided into three groups. According to the statistical analysis, a statistically significant direct relationship of chronological and biological age (p<0.0001; r=0.82). The biological age was significantly higher in the obese group (p=0.0098), compared with the control group. Δ age is lower in group 1 compared to group 2 (p=0.0003). There was a significant inverse correlation of age with insulin (r=-0.3859; p=0.0036), HOMA index (r=-0.4291; p=0.0011) and BMI (r=-0.4886; p<0.0001). Separately, a significant decrease in biological age was revealed against the background of weight loss in the considered clinical cases. Conclusion. During the study, it was possible to identify higher values of biological age in the obese group, compared with the control group; with weight loss, a significant decrease in biological age was revealed. Keywords: biological age, aging, obesity, adipose tissue, inflammaging.

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