Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial
Rattachement africain : cz, us, si. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Liver function is foundational to human health. While numerous herbal extracts have individually been shown to improve liver function, there are relatively few studies on combinations of herbal ingredients that may have synergistic effects. In addition, capsule fatigue is a common problem when aiming to incorporate multiple ingredients to support liver health. With these gaps in mind, the goal of this study was to evaluate the safety and efficacy of a highly purified plant-based nutraceutical containing organic herbal extracts of turmeric, dandelion, milk thistle, and ginger on liver function parameters. Methods: A randomized, placebo-controlled clinical trial was conducted to evaluate the efficacy of this nutraceutical liquid formula. Healthy adults were randomized 1:1 to receive the nutraceutical product or placebo (both 60 mL) twice daily for 180 days. The primary endpoint was change in liver function tests (alanine aminotransferase [ALT], aspartate aminotransferase [AST], alanine phosphatase [ALP], gamma-glutamyl transferase [GGT]) from baseline to end of study. Safety was also evaluated. The primary endpoint was compared between study arms via analysis of covariance. Results: ≤ 0.001). No adverse events were reported. Discussion: Supplementation with this liquid nutraceutical formula improved the liver enzyme profile of healthy individuals, suggesting that it may mitigate a trend toward higher liver enzyme levels over time in a convenient manner that fosters compliance. Clinical trial registration: https://ctri.nic.in/Clinicaltrials/login.php, CTRI/2023/06/054492.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Long-term safety and efficacy of a highly purified plant-based nutraceutical for improving clinical parameters of liver function in healthy participants: a randomized, double-blind, placebo-controlled clinical trial
- Date Crossref
- 23/01/2026
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Green Solution (Czechia) pays non établi dans la noticeEntreprise
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Unity Hospital Unity Trauma Centre and ICU pays non établi dans la noticeÉtablissement de santé
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University of Maryland Department of Family and Community Medicine pays non établi dans la noticeUniversité ou école supérieure
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XLAB (Slovenia) pays non établi dans la noticeEntreprise
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Ovation Fertility pays non établi dans la noticeÉtablissement de santé
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Green Medic Solution pays non établi dans la noticeInstitution
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OvationLab pays non établi dans la noticeStructure de recherche
Green Solution (Czechia), Unity Trauma Centre and ICU — Unity Hospital et Department of Family and Community Medicine — University of Maryland, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.