Additional file 5 of Disordered DNA methylation leads to targetable transcriptional plasticity in ATRT

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Supplementary Material 5. Figure 5. Gene Enrichments in ATRT cell lines after treatment with decitabine and RG2833. A) Top 4 Gene Ontology enrichments from GOrilla in CHLA02, CHLA05, and CHLA266 for all genes upregulated in combination treatment relative to DMSO. All enrichments were significant (gene ontology = y-axis; -log10(p-value) = x-axis). B) “WANG_SMARCE1_TARGETS_UP” enrichments from GSEA for 2 ATRT cell lines: CHLA02 and CHLA05 (cell line, y-axis; -log10(p-value), x-axis). C) “NUYTTEN_EZH2_TARGETS_UP” enrichments from GSEA for all 4 ATRT cell lines: CHLA02, CHLA05, CHLA06, and CHLA266 (cell line, y-axis; -log10(p-value), x-axis). D) Western blots of IFITM3 protein expression in CHLA02 (left) and CHLA06 (right), from the same experiment as presented in figure 4c. GAPDH is repeated here as the loading control. Treatment conditions from left to right are: DMSO, 5 µM RG2833, 100 nM DAC, combination.

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