Association between systemic immune-inflammatory markers and monoclonal gammopathy of undetermined significance in the elderly population: findings from the National health and nutrition examination survey

Le résumé fourni par la source

BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma cell disorder whose prevalence increases with age and may progress to multiple myeloma. The tumor microenvironment plays a crucial role in MGUS pathogenesis and progression. Systemic immune-inflammatory markers can reflect tumor microenvironment(TME) dynamics, but their association with MGUS odds remains understudied. METHODS: This cross-sectional study analyzed data from 12,080 adults aged ≥ 50 years (including 350 MGUS cases) in the National Health and Nutrition Examination Survey (NHANES III and 1999-2004 cycles). Multivariable logistic regression assessed associations between systemic immune-inflammatory markers [lymphocyte-to-monocyte ratio(LMR), Platelet-to-lymphocyte ratio(PLR), Hemoglobin, albumin, lymphocyte, platelet score(HALP), and their individual components] and MGUS. Generalized additive models identified nonlinear relationships and threshold effects across stratified groups. RESULTS: Higher LMR quartiles were positively associated with MGUS prevalence (Q4 vs. Q1: OR = 1.454, 95% CI 1.048-2.016), while elevated monocyte counts (OR = 0.624, 95% CI 0.456-0.853) and albumin levels (OR = 0.446, 95% CI 0.317-0.627) correlated with reduced MGUS odds. Nonlinear analysis revealed a U-shaped association between PLR and MGUS. There are race-specific nonlinear correlations involving LMR, PLR, and lymphocyte counts with MGUS. CONCLUSIONS: Systemic immune-inflammatory markers are significantly associated with MGUS odds in older adults, highlighting their potential for early detection and longitudinal monitoring.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.