Human Immunodeficiency Virus–Associated Proteomic Signature of Myocardial Fibrosis and Incident Heart Failure
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Le résumé fourni par la source
BACKGROUND: People with human immunodeficiency virus (HIV) (PWH) are at higher risk of myocardial fibrosis and subsequent heart failure (HF) compared to people without HIV (PWOH). Mechanisms underlying this risk and its specificity to PWH are unclear. METHODS: We measured 2594 proteins in plasma obtained concurrently with cardiovascular magnetic resonance imaging among 342 PWH and PWOH. We estimated associations with HIV serostatus and myocardial fibrosis (elevated extracellular volume fraction [ECV] ≥30% among women, ≥28% among men) using multivariable regression. Among an independent community-based cohort, we estimated associations between the identified signature and time to incident HF. RESULTS: Mean age of participants was 55 (standard deviation [SD], 6) years, 25% were female, 61% were PWH (88% on antiretroviral therapy, 74% with undetectable HIV RNA), and 52% had elevated ECV. We identified 39 proteins and 1 cluster of 42 proteins that were higher among PWH versus PWOH and positively associated with elevated ECV, independent of risk factors (false discovery rate <0.05). Among an independent cohort of 3223 PWOH (mean age, 68 [SD, 9] years; 52% female; 118 incident HF cases over a mean of 9.8 [SD, 1.4] years), we found that this protein cluster and 34 of 39 individual proteins were associated with time to incident HF. This signature was statistically enriched for T-cell activation, tumor necrosis factor signaling, ephrin signaling, and tissue maintenance and repair. CONCLUSIONS: We identified an HIV-related proteomic signature associated with myocardial fibrosis regardless of HIV serostatus and that predicted incident HF among the general population. Our results identify several novel associations related to specific immune processes that may contribute to risk of myocardial fibrosis and subsequent HF among both PWH and PWOH.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Human Immunodeficiency Virus–Associated Proteomic Signature of Myocardial Fibrosis and Incident Heart Failure
- Date Crossref
- 12/01/2026
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Minnesota Division of Epidemiology and Community Health pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Medicine pays non établi dans la noticeÉtablissement de santé
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Minnesota Department of Health pays non établi dans la noticeOrganisme public
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Institute on Aging pays non établi dans la noticeOrganisation à but non lucratif
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National Institute on Aging pays non établi dans la noticeStructure de recherche
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Northwestern University Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
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Georgetown University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Beth Israel Deaconess Medical Center Division of Cardiovascular Medicine pays non établi dans la noticeÉtablissement de santé
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UCLA Medical Center pays non établi dans la noticeÉtablissement de santé
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Biomedical Research Center pays non établi dans la noticeStructure de recherche
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Johns Hopkins Bloomberg School of Public Health Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
Division of Epidemiology and Community Health — University of Minnesota, Department of Medicine — Johns Hopkins University et Johns Hopkins Medicine, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.