Shigella sonnei and Shigella flexneri : Epidemiology supporting development of cross-protective vaccines

Le résumé fourni par la source

Shigellosis represents a major global health challenge, significantly contributing to mortality among children under five, particularly in sub-Saharan Africa and South Asia. Advances in molecular techniques have underscored the extensive global impact of Shigella, and the spread of multi- and extensively drug-resistant strains has sharply escalated the threat, emphasizing the urgent need for innovative interventions. Developing a broadly protective vaccine with a positive benefit-risk profile remains a critical and challenging objective due to the diversity of Shigella serotypes mediated by the immune dominance of the O-antigen. This review analyzes the distribution of Shigella serotypes in both endemic and non-endemic regions and examines the impact of O-antigen diversity on cross-reactivity. Various vaccine strategies, with a particular focus on the O-antigen as a key antigenic target, will be presented, highlighting the need for an effective vaccine especially due to the increased antimicrobial resistance associated to this pathogen. Overall, this review aims to provide a thorough understanding of different aspects of Shigella epidemiology with the aim to support development of effective control strategies against Shigella thus contributing to efforts against the escalating antimicrobial resistance crisis.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.