Estimating the Transmission Potential of Symptomatic and Asymptomatic Cholera Cases from Household Microbiological and Clinical Data
Rattachement africain : us, bd, ch. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: In Bangladesh, cholera treatment focuses on acute watery diarrhea in symptomatic cases at health facilities, though asymptomatic infections are common. Understanding the role of asymptomatic infections in transmission is crucial for designing appropriate control strategies in this setting. Methods: We utilized data from household studies conducted in Dhaka, Bangladesh during 2006-2018 where a symptomatic confirmed cholera case and their household contacts were followed for thirty days. Vibriocidal antibodies, bacteriological culture, and symptom histories were collected at multiple times points. We used a hidden Markov model to estimate risk of infection from intra-household and extra-household (i.e., community and environmental) sources and to quantify relative risk of transmission from symptomatic and asymptomatic infected household contacts. Results: Estimated daily risk of intra-household infection from a symptomatic individual to another household member was 2.6% (95% CI: 0.4% - 5.6%) and from an asymptomatic infected individual to another household member was 1.6% (95% CI: 0.2% - 4.5%). We found no significant differences in probability of infection from asymptomatic compared to symptomatic individuals (OR: 0.60; 95% CI: 0.11 - 3.23). We estimated that daily risk of infection from extra-household sources during follow-up was 1.0% (95% CI: 0.7% - 1.4%). Conclusion: Mitigation measures focused solely on treatment of symptomatic cholera cases may be insufficient to prevent transmission in a household. This supports use of interventions that reduce risk of transmission irrespective of symptoms, such as prophylactic antibiotic treatment for household members and/or providing safe water and hygiene kits following a confirmed household or community case.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Estimating the Transmission Potential of Symptomatic and Asymptomatic Cholera Cases from Household Microbiological and Clinical Data
- Date Crossref
- 11/01/2026
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of North Carolina at Chapel Hill Carolina Population Center pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins University pays non établi dans la noticeUniversité ou école supérieure
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International Centre for Diarrhoeal Disease Research pays non établi dans la noticeStructure de recherche
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Harvard University pays non établi dans la noticeUniversité ou école supérieure
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Massachusetts General Hospital Division of Infectious Diseases pays non établi dans la noticeÉtablissement de santé
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University of Washington Department of Global Health pays non établi dans la noticeUniversité ou école supérieure
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Seattle University pays non établi dans la noticeUniversité ou école supérieure
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University of Geneva Institute of Global Health pays non établi dans la noticeUniversité ou école supérieure
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University Hospital of Geneva pays non établi dans la noticeÉtablissement de santé
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Temple University Department of Epidemiology and Biostatistics pays non établi dans la noticeUniversité ou école supérieure
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University of North Carolina Gillings School of Public Health Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Bloomberg School of Public Health Department of Epidemiology pays non établi dans la noticeUniversité ou école supérieure
Carolina Population Center — University of North Carolina at Chapel Hill, Johns Hopkins University et International Centre for Diarrhoeal Disease Research, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.