Accès ouvert déclaré
2026
article
Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort
Javier Llorca, Ferraz-Amaro Ivan, María José Moreno-Martínez, Zulema Plaza, F. Sánchez-Alonso, Manuel José Moreno Ramos, Carmen García-Gómez, Santos Castañeda, Carlos González-Juanatey, Miguel Á. González‐Gay, José L Fernández Sueiro, José A. Pinto-Tasende, Eugenia Gonzalez de Rábago, Maria J Fernandez, Ramón Huguet Codina, Beatriz Yoldi, Mercedes Ramentol, Sara Marsal, Gabriela Ávila, Cayetano Alegre, Martina Steiner, Tatiana Cañeque Cobo, Santiago León Atehortúa Muñoz, Fernando Gamero, José García Torón, María Pilar Gil, Antonio J. Mas, Pilar Espiño, Inmaculada Ros, Mónica Ibáñez, J.D. Tornero, José A. Piqueras, Raimon Sanmartí, Horacio Berman, Oscar Fontseré Patón, Benjamín Fernández Gutiérrez, Lydia Abasolo, José M. Pina Salvador, María D. Fábregas, Montserrat Romera, Joan M. Nolla, Miren Uriarte-Ecenarro, Miriam García Arias, Jesús A. García Vadillo, Rosario García de Vicuña, Eugenio Chamizo Carmona, Antonio Fernández. Nebro, Inmaculada Ureña, María Ángeles Belmonte, María Victoria Irigoyen, Olga Martínez González, Rebeca Belmonte Gómez, Pastora Granados Bautista, Azucena Hernández Sanz, José Santos Rey, Carmen O. Sánchez González, Javier Bachiller, Antonio Zea, Francisco J. Manero, Chesús Beltrán Audera, Marta Medrano, Ángela Pecondón, Celia Erausquin, Soledad Ojeda, Carlos Rodríguez-Lozano, Jesús BabíoHerraiz, Francisco J. López Longo, I. Monteagudo, Javier del Pino, Ruth López González, Alfonso Corrales, José M. Senabre, José C. Rosas, Isabel Rotés, Estefanía Moreno, Alba Erra, Javier Calvo, Amalia Rueda, Ingrid Möller, Isabel Hernandez Rodriguez, C. Barbadillo, Enrique Raya, Pilar Morales, Ana Lucía Ruano Ruano Nieto, Ana Ruibal Escribano, Carmen García Gómez, Sergio Ros Expósito, Ginés Sánchez Nievas, Enrique Júdez Navarro, Manuela Sianes Fernández, Sílvia Martínez Pardo, Manel Pujol, Beatriz GónzálezAlvarez, A. Cantabrana, Sagrario Bustabad, Esmeralda Delgado, Alejandro Martínez Muñoz, Sergio Rodríguez Montero, Javier Rivera Redondo, Teresa González Hernández, Francisco J. González Polo, Raúl Menor Almagro, José M. Moreno, Emilio Giner Serret, Laura Cebrián Méndez, María Teresa Navío, Teresa Pedraz Penalva, Cristina Fernández‐Carballido, Encarnación Pagán, P. Mesa del Castillo, E. Naredo, Ana C. Cruz, Ana Isabel Turrión, A. Pérez Gómez, Julio García Sánchez, María Galindo-Izquierdo, Eduardo Collantes, Desireé Ruíz, Pilar Font, Gema Ruíz Bonilla, Antonio López Meseguer, Manuel J. Moreno, L. Linares, Mercedes Morcillo, María L. González Gómez, José M. Aramburu, Natalia A. Rivera, Olaia Fernández. Berrizbeitia, Hyesang Park, Manel Riera, Yolanda María León, Carolina Pérez-García, Joan Maymó, Miriam Amirall, Jordi Fiter, Julia Fernández Melón, Luís Espadaler, Joaquín Belzunegui, Inmaculada Bañegil, César Díaz, Ramón Valls, I. Castellví, María Bonet, Jaime Calvo Alén, T. Pérez Sandoval, E Evrard, J Godo, José Antonio González Fernández, José A. Miranda-Filloy
2Citations signalées, ce qui n’est pas une note de qualité
11Institutions déclarées
1Pays d’affiliation déclarés
Rattachement africain : es.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVE: To identify predictors of cardiovascular (CV) events in psoriatic arthritis (PsA) patients from the CARdiovascular in RheuMAtology (CARMA) project during 10 years of prospective follow-up. METHODS: Between July 2010 and January 2012, 725 PsA patients were enrolled from 67 Spanish hospitals. Analyses focused on 682 patients without prior CV events at baseline. At 10-year follow-up, CV event occurrence, patient-years, and linearized event rates were evaluated. Cox regression analyses were performed, both crude and adjusted for the PREVENT-CVD score. RESULTS: Over 6397 patient-years, 85 patients (12.46%) experienced CV events, yielding a rate of 1.33 per 100 patient-years. Patients with CV events were older (67.1 ± 11.1 vs. 56.7 ± 11.8 years, p < 0.001), more often male (68.2% vs. 51.9%, p = 0.005), and had higher frequencies of hypertension (60.0% vs. 21.8%, p < 0.001), diabetes (18.8% vs. 6.0%, p = 0.001), and dyslipidemia (56.5% vs. 29.8%, p < 0.001). They also showed greater abdominal perimeter and body mass index (p < 0.05 for both). After adjusting for PREVENT-CVD, the highest tertile of DAS28-ESR remained a significant predictor of CV events (HR 1.79; 95%CI: 1.03-3.14; p = 0.04). Urate in the highest tertile was also independently associated in the crude model (HR 1.88; 95%CI: 1.11-3.20; p = 0.02). When stratified (<6.5, 6.5-8.9, and ≥9.0 mg/dl), urate≥9.0 mg/dl was also associated with increased risk of CV events in the adjusted model (HR 3.50; 95%CI: 1.10-11.2; p = 0.02). While HAQ score in the third tertile was associated with increased CV risk in the crude analysis (HR 1.70; p = 0.04), this association did not persist after adjustment. CONCLUSIONS: Disease activity and elevated urate levels independently predict CV events in PsA, highlighting their value as markers of CV risk beyond traditional factors captured by the PREVENT-CVD score.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Disease activity and hyperuricemia predict the development of cardiovascular events in patients with Psoriatic Arthritis: results of the 10-year prospective evaluation in the CARMA cohort
- Date Crossref
- 01/04/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Gout, Hyperuricemia, Uric AcidSpondyloarthritis Studies and TreatmentsRheumatoid Arthritis Research and Therapies