Association Between Isolated Postprandial Dyslipidemia And Erectile Dysfunction
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Le résumé fourni par la source
BACKGROUND: Postprandial lipid testing is increasingly recognized as a marker of vascular health. However, its relationship with erectile dysfunction (ED) remains largely unexplored. Isolated postprandial dyslipidemia (IPD), in particular, may evade detection using conventional fasting-based assessments, despite potential atherogenic effects. OBJECTIVES: To evaluate the association between IPD and erectile function, comparing the prevalence and severity of ED among men with IPD, combined dyslipidemia (CD), and those without dyslipidemia (WD). MATERIALS AND METHODS: In this cross-sectional study, sexually active men aged ≥18 years underwent same-day fasting and postprandial lipid testing, as well as erectile function evaluation using the International Index of Erectile Function - Erectile Function domain (IIEF-EF) questionnaire. Dyslipidemia was defined according to the 2019 European Society of Cardiology/European Atherosclerosis Society criteria. Patients were categorized as WD (no dyslipidemia), IPD (postprandial abnormalities only), or CD (both fasting and postprandial abnormalities). Multivariable logistic regression was performed, adjusting for age, smoking status, BMI, and hypertension. The primary outcome was the prevalence of ED (IIEF-EF ≤25); secondary outcomes included ED severity and comparisons across lipid profile subgroups. RESULTS: Among 351 men, ED prevalence was higher in the IPD (55.1%) and CD (57.0%) groups compared to WD (32.8%; p < 0.001). Median (IQR) IIEF-EF scores were 26 (25-28) in the WD group, 22 (20-23) in the IPD group, and 21 (19-23) in the CD group. The differences between WD and both IPD and CD exceeded the minimal clinically important difference (4 points) and were statistically significant (p < 0.001). Adjusted analyses confirmed increased odds of ED in IPD (odds ratio [OR] = 2.36; 95% confidence interval [CI]: 1.41-3.96) and CD (OR = 2.58; 95% CI: 1.43-4.65) versus WD. ED severity was also greater in the IPD and CD groups. No differences emerged between IPD and CD in any outcome. Among IPD subtypes, elevated postprandial triglycerides were most common, but no single lipid abnormality was independently associated with ED severity. CONCLUSION: IPD is associated with both the prevalence and severity of ED, paralleling the impact of chronic dyslipidemia. Postprandial lipid testing may reveal hidden metabolic risks relevant to sexual health and should be considered in the evaluation of ED. CLINICAL TRIAL REGISTRATION: Not applicable.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association Between Isolated Postprandial Dyslipidemia And Erectile Dysfunction
- Date Crossref
- 09/01/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Campania "Luigi Vanvitelli" pays non établi dans la noticeUniversité ou école supérieure
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Federico II University Hospital pays non établi dans la noticeÉtablissement de santé
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University of Catania pays non établi dans la noticeUniversité ou école supérieure
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Ospedale di Circolo e Fondazione Macchi pays non établi dans la noticeÉtablissement de santé
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Department of Woman Child and General and Specialized Surgery Unit of Urology University of Campania “Luigi Vanvitelli” Naples Italy pays non établi dans la noticeUniversité ou école supérieure
University of Campania "Luigi Vanvitelli", Federico II University Hospital et University of Catania, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.