Supplementary Figure S8 from T-cell Subset Features and Distributions Evolve across the Colorectal Precancer–Cancer Spectrum

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Supplementary Figure S8. The combined T-cell status of precursor tissue categories in relation to lesion size, age of resection, and anatomic location. (A-D) CD3+CD4+ and CD3+CD8+ T-cells’ densities stratified by precursor lesions’ size, which includes small (lesion size: <5 mm), medium (5-9 mm), and large (≥10 mm) in non-serrated and serrated lesions. (E-H) CD3+CD4+ and CD3+CD8+ T-cells’ densities stratified by age of resection, which includes early-onset (age <50 years), intermediate-onset (age 50-54 years), and later-onset (age 55-69 and ≥70 years). P values were calculated with the Mann-Whitney U test (Wilcoxon rank-sum test) as compared to each adenoma category in (A-D) and colorectal normal mucosa near precursor lesions (Normal mucosa) in (E-H). ***: P <0.0005, **: P <0.005, *: P <0.05. Abbreviations: Non-serrated, non-serrated adenomas, Normal, colorectal normal mucosa near precursor lesions; Serrated, serrated lesions.

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